DegronMD

Uniprot ID: P98088

Source protein: Mucin-5AC

Source gene: MUC5AC

Class: DEG_SPOP_SBC_1

Location: 2808:2812

E3 ligase: SPOP

DEGRON score: 0.8491

ASA_SCORE: 90.36

COIL: 0.9118

CONS_SCORE: 0.2964

DSS_SCORE: 0.5935

HELIX: 0.0148

FCONS_SCORE: 0.877

RIG_SCORE: 0.6471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2822L	SIDM00944	Colorectal Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00987	Thyroid Gland Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00776	Colorectal Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00042	Pancreatic Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00284	Melanoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00813	Non-Cancerous	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00631	Breast Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00796	Head and Neck Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00767	Small Cell Lung Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM00124	Kidney Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S2822L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.T2804R	SIDM00251	Gastric Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons