DegronMD - Q99935(OPRPN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L34M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	37:40	Mutation rewiring degron network	0.25
p.L63F	SIDM00993	Plasma Cell Myeloma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00435	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00578	Neuroblastoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00411	Pancreatic Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00535	Chondrosarcoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01199	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00555	Glioblastoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00193	Colorectal Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00060	Ovarian Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00568	Gastric Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00596	Endometrial Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00358	Gastric Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01045	Endometrial Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00360	Other Solid Cancers	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00817	Kidney Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00054	Pancreatic Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00564	Ovarian Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00214	Colorectal Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00907	Burkitt's Lymphoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00970	Bladder Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00882	Breast Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00018	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00616	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00655	Other Solid Cancers	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01217	Other Blood Cancers	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00271	Gastric Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00613	Glioblastoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00503	Gastric Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00302	Other Solid Cancers	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01439	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01569	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01612	Endometrial Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01570	Ovarian Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00169	Head and Neck Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01444	Glioblastoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01578	Bladder Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00008	Ovarian Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01347	Ovarian Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00161	Biliary Tract Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01658	Unknown	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01321	Pancreatic Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM01587	Bladder Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.A194T	SIDM00108	Melanoma	GDSC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833
p.A194T	UACC-257	skin	COSMIC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833
p.P186A	SIDM00678	Bladder Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.P186A	HT-1376	urinary tract	COSMIC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.P186T	SIDM00120	Prostate Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.P186T	DU-145	prostate	COSMIC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.P181S	SIDM00917	Acute Myeloid Leukemia	GDSC	PISST	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6752
p.P181S	CESS	haematopoietic and lymphoid tissue	COSMIC	PISST	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6752
p.L39P	SIDM00694	Other Solid Cancers	GDSC	PPLY	ITCH	37:40	Mutation altering degron motif	0.6471
p.L39P	SIDM00254	Neuroblastoma	GDSC	PPLY	ITCH	37:40	Mutation altering degron motif	0.6471
p.L39P	HUTU-80	small intestine	COSMIC	PPLY	ITCH	37:40	Mutation altering degron motif	0.6471
p.L39P	NB5	autonomic ganglia	COSMIC	PPLY	ITCH	37:40	Mutation altering degron motif	0.6471
p.P51L	SIDM01608	Endometrial Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OPRPN

UniProt ID: Q99935

Entrez ID: 58503

Protein name: Opiorphin prepropeptide (Basic proline-rich lacrimal protein) (Proline-rich protein 1) (PRL1) [Cleaved into: Opiorphin]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OPRPN in