DegronMD - Q99935(OPRPN)

FUNCTION: Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. {ECO:0000269|PubMed:17101991}.

GO - Biological processes (BP): regulation of sensory perception of pain [GO:0051930]; retina homeostasis [GO:0001895]

GO - Molecular function (MF): endopeptidase inhibitor activity [GO:0004866]; peptidase inhibitor activity [GO:0030414]

GO - Cellular component (CC): extracellular region [GO:0005576]; extracellular space [GO:0005615]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
ATTST	DEG_SPOP_SBC_1	SPOP	Opiorphin prepropeptide	163:167	More..
PISST	DEG_SPOP_SBC_1	SPOP	Opiorphin prepropeptide	181:185	More..
PPLY	ITCH	ITCH,NEDD4	Opiorphin prepropeptide	37:40	More..
PPPY	ITCH	ITCH,NEDD4	Opiorphin prepropeptide	50:53	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P51L	SIDM01608	Endometrial Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation altering degron motif	0.7582
p.P181S	SIDM00917	Acute Myeloid Leukemia	GDSC	PISST	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6752
p.P181S	CESS	haematopoietic and lymphoid tissue	COSMIC	PISST	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6752
p.L39P	SIDM00694	Other Solid Cancers	GDSC	PPLY	ITCH	37:40	Mutation altering degron motif	0.6471
p.L39P	SIDM00254	Neuroblastoma	GDSC	PPLY	ITCH	37:40	Mutation altering degron motif	0.6471
p.L39P	HUTU-80	small intestine	COSMIC	PPLY	ITCH	37:40	Mutation altering degron motif	0.6471
p.L39P	NB5	autonomic ganglia	COSMIC	PPLY	ITCH	37:40	Mutation altering degron motif	0.6471
p.P186A	SIDM00678	Bladder Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.P186A	HT-1376	urinary tract	COSMIC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.P186T	SIDM00120	Prostate Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.P186T	DU-145	prostate	COSMIC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.L34M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	37:40	Mutation rewiring degron network	0.25
p.A194T	SIDM00108	Melanoma	GDSC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833
p.A194T	UACC-257	skin	COSMIC	PISST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833
p.L63F	SIDM00993	Plasma Cell Myeloma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00435	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00578	Neuroblastoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00411	Pancreatic Carcinoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.L63F	SIDM00535	Chondrosarcoma	GDSC	PPPY	ITCH	50:53	Mutation rewiring degron network	0.0556

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Kaplan plot for OPRPN in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

OPRPN

UniProt ID: Q99935

Entrez ID: 58503

Protein name: Opiorphin prepropeptide (Basic proline-rich lacrimal protein) (Proline-rich protein 1) (PRL1) [Cleaved into: Opiorphin]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OPRPN in