DegronMD

Uniprot ID: Q99935

Source protein: Opiorphin prepropeptide

Source gene: OPRPN

Class: DEG_SPOP_SBC_1

Location: 181:185

E3 ligase: SPOP

DEGRON score: 0.9979

ASA_SCORE: 78.2

COIL: 0.9234

CONS_SCORE: 1

DSS_SCORE: 0.5725

HELIX: 0.0136

FCONS_SCORE: 1.1444

RIG_SCORE: 0.6459

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A194T	SIDM00108	Melanoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0833
p.A194T	UACC-257	skin	COSMIC	PISST	DEG_SPOP_SBC_1	0.0833
p.P186A	SIDM00678	Bladder Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.3056
p.P186A	HT-1376	urinary_tract	COSMIC	PISST	DEG_SPOP_SBC_1	0.3056
p.P186T	SIDM00120	Prostate Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.3056
p.P186T	DU-145	prostate	COSMIC	PISST	DEG_SPOP_SBC_1	0.3056
p.P181S	SIDM00917	Acute Myeloid Leukemia	GDSC	PISST	DEG_SPOP_SBC_1	0.6752
p.P181S	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	PISST	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons