DegronMD - Q8IW35(CEP97)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D390N	TCGA-44-3919	LUAD	TCGA	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation rewiring degron network	0.1944
p.D390N	DO25757	LUAD	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation rewiring degron network	0.1944
p.T389M	TCGA-55-7913	LUAD	TCGA	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation rewiring degron network	0.2222
p.T389M	DO223665	LUAD	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation rewiring degron network	0.2222
p.T659I	TCGA-AA-A010	COAD	TCGA	PISST	DEG_SPOP_SBC_1	655:659	Mutation altering degron motif	0.7078
p.E692D	TCGA-D1-A16X	UCEC	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1111
p.E692D	TCGA-DK-A6AW	BLCA	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1111
p.E692D	TCGA-EO-A3AV	UCEC	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1111
p.R379Q	TCGA-D1-A17L	UCEC	TCGA	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation altering degron motif	0.7329
p.R379Q	DO40847	UCEC	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation altering degron motif	0.7329
p.P654H	TCGA-EE-A2MM	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.S371Y	TCGA-EO-A22R	UCEC	TCGA	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation blocking phosphorylation signal	0.5556
p.S371Y	DO42713	UCEC	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation blocking phosphorylation signal	0.5556
p.P655S	TCGA-FS-A1ZS	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	655:659	Mutation altering degron motif	0.6752
p.P655S	DO50970	LICA	ICGC	PISST	DEG_SPOP_SBC_1	655:659	Mutation altering degron motif	0.6752
p.P699S	TCGA-Q1-A73O	CESC	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.3056
p.S694L	TCGA-WE-AAA0	SKCM	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation blocking phosphorylation signal	0.6111
p.L712P	DO224763	BRCA	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1667
p.E662K	DO224920	BRCA	ICGC	PISST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.25
p.T375M	DO222421	BTCA	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation rewiring degron network	0.2222
p.R379L	DO229019	LICA	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation altering degron motif	0.8428
p.G690V	DO26993	LUSC	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.0556
p.E695K	DO26617	LUSC	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1944
p.Q648E	DO50082	OV	ICGC	PISST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1389
p.H696R	DO51752	STAD	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.2222
p.S711N	DO41235	UCEC	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1944
p.H704Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation altering degron motif	0.6118
p.H704Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation altering degron motif	0.6118
p.H704Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation altering degron motif	0.6118
p.S658I	SIDM00333	Endometrial Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	655:659	Mutation altering degron motif	0.7341
p.S658I	MFE-319	endometrium	COSMIC	PISST	DEG_SPOP_SBC_1	655:659	Mutation altering degron motif	0.7341
p.L384P	SIDM00208	Glioblastoma	GDSC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation altering degron motif	0.6471
p.L384P	ACH-002229	Brain Cancer	CCLE	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation altering degron motif	0.6471
p.L384P	D-502MG	central nervous system	COSMIC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	379:385	Mutation altering degron motif	0.6471
p.E692K	SIDM01102	Non-Cancerous	GDSC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1111
p.E692K	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1111
p.V692I	ACH-000523	Lung Cancer	CCLE	DSGFHSS	DEG_SCF_TRCP1_1	700:706	Mutation rewiring degron network	0.1111
p.H645Y	ACH-000995	Leukemia	CCLE	PISST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.0556
p.H645Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PISST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.0556
p.D660N	ACH-000999	Colon/Colorectal Cancer	CCLE	PISST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.D660N	SNU-1040	large intestine	COSMIC	PISST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP97

UniProt ID: Q8IW35

Entrez ID: 79598

Protein name: Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP97 in