DegronMD

Uniprot ID: Q8IW35

Source protein: Centrosomal protein of 97 kDa

Source gene: CEP97

Class: DEG_SCF_TRCP1_1

Location: 700:706

E3 ligase: BTRC

DEGRON score: 0.99

ASA_SCORE: 67.3857

COIL: 0.7924

CONS_SCORE: 0.3715

DSS_SCORE: 0.5516

HELIX: 0.1593

FCONS_SCORE: 0.9651

RIG_SCORE: 0.6349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E692D	TCGA-D1-A16X	UCEC	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	0.1111
p.E692D	TCGA-DK-A6AW	BLCA	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	0.1111
p.E692D	TCGA-EO-A3AV	UCEC	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	0.1111
p.P699S	TCGA-Q1-A73O	CESC	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	0.3056
p.S694L	TCGA-WE-AAA0	SKCM	TCGA	DSGFHSS	DEG_SCF_TRCP1_1	0.6111
p.L712P	DO224763	BRCA	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	0.1667
p.G690V	DO26993	LUSC	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	0.0556
p.E695K	DO26617	LUSC	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	0.1944
p.H696R	DO51752	STAD	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	0.2222
p.S711N	DO41235	UCEC	ICGC	DSGFHSS	DEG_SCF_TRCP1_1	0.1944
p.H704Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGFHSS	DEG_SCF_TRCP1_1	0.6118
p.H704Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGFHSS	DEG_SCF_TRCP1_1	0.6118
p.H704Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFHSS	DEG_SCF_TRCP1_1	0.6118
p.E692K	SIDM01102	Non-Cancerous	GDSC	DSGFHSS	DEG_SCF_TRCP1_1	0.1111
p.E692K	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFHSS	DEG_SCF_TRCP1_1	0.1111
p.V692I	ACH-000523	Lung Cancer	CCLE	DSGFHSS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IW35	Centrosomal protein of 97 kDa	DEG_SCF_TRCP1_1	700:706	DSGFHSS	BTRC	0.99	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons