DegronMD

Uniprot ID: Q8IW35

Source protein: Centrosomal protein of 97 kDa

Source gene: CEP97

Class: LIG_APCC_ABBAyCdc20_2

Location: 379:385

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.95

ASA_SCORE: 103.1571

COIL: 0.7049

CONS_SCORE: 0.4307

DSS_SCORE: 0.4023

HELIX: 0.165

FCONS_SCORE: 0.9481

RIG_SCORE: 0.7698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D390N	TCGA-44-3919	LUAD	TCGA	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D390N	DO25757	LUAD	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.T389M	TCGA-55-7913	LUAD	TCGA	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.T389M	DO223665	LUAD	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R379Q	TCGA-D1-A17L	UCEC	TCGA	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R379Q	DO40847	UCEC	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.7329
p.S371Y	TCGA-EO-A22R	UCEC	TCGA	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.5556
p.S371Y	DO42713	UCEC	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.5556
p.T375M	DO222421	BTCA	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R379L	DO229019	LICA	ICGC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.8428
p.L384P	SIDM00208	Glioblastoma	GDSC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.6471
p.L384P	ACH-002229	Brain Cancer	CCLE	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.6471
p.L384P	D-502MG	central_nervous_system	COSMIC	RNDLHLE	LIG_APCC_ABBAyCdc20_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IW35	Centrosomal protein of 97 kDa	LIG_APCC_ABBAyCdc20_2	379:385	RNDLHLE	APC,CDC20,FZR1	0.95	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons