DegronMD

Uniprot ID: Q8IW35

Source protein: Centrosomal protein of 97 kDa

Source gene: CEP97

Class: DEG_SPOP_SBC_1

Location: 655:659

E3 ligase: SPOP

DEGRON score: 0.9197

ASA_SCORE: 91.1

COIL: 0.9184

CONS_SCORE: 0.4101

DSS_SCORE: 0.384

HELIX: 0.0516

FCONS_SCORE: 1.0879

RIG_SCORE: 0.6984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T659I	TCGA-AA-A010	COAD	TCGA	PISST	DEG_SPOP_SBC_1	0.7078
p.P654H	TCGA-EE-A2MM	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	0.3056
p.P655S	TCGA-FS-A1ZS	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	0.6752
p.P655S	DO50970	LICA	ICGC	PISST	DEG_SPOP_SBC_1	0.6752
p.E662K	DO224920	BRCA	ICGC	PISST	DEG_SPOP_SBC_1	0.25
p.Q648E	DO50082	OV	ICGC	PISST	DEG_SPOP_SBC_1	0.1389
p.S658I	SIDM00333	Endometrial Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.7341
p.S658I	MFE-319	endometrium	COSMIC	PISST	DEG_SPOP_SBC_1	0.7341
p.H645Y	ACH-000995	Leukemia	CCLE	PISST	DEG_SPOP_SBC_1	0.0556
p.H645Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PISST	DEG_SPOP_SBC_1	0.0556
p.D660N	ACH-000999	Colon/Colorectal Cancer	CCLE	PISST	DEG_SPOP_SBC_1	0.3056
p.D660N	SNU-1040	large_intestine	COSMIC	PISST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons