DegronMD - Q9HBT6(CDH20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A537T	TCGA-22-4599	LUSC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.6028
p.A537T	DO26945	LUSC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.6028
p.R554Q	TCGA-66-2754	LUSC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.0833
p.R554Q	DO27612	LUSC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.0833
p.E361K	TCGA-86-8279	LUAD	TCGA	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1667
p.E361K	DO24140	LUAD	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1667
p.A537S	TCGA-86-A4JF	LUAD	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.6477
p.A537S	DO229015	LICA	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.6477
p.A537S	DO45317	LUAD	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.6477
p.P358T	TCGA-98-8022	LUSC	TCGA	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0833
p.P358T	DO26934	LUSC	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0833
p.P358T	SIDM01768	Melanoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0833
p.P358T	ACH-000899	Skin Cancer	CCLE	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0833
p.N540S	TCGA-AA-3949	COAD	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.5958
p.N540S	DO7798	COAD	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.5958
p.E361Q	TCGA-AC-A23H	BRCA	TCGA	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1667
p.E361Q	DO2401	BRCA	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1667
p.R524H	TCGA-AJ-A3BG	UCEC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.0833
p.R524H	DO42633	UCEC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.0833
p.A553V	TCGA-AX-A1C4	UCEC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.1111
p.A553V	DO42480	UCEC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.1111
p.F529V	TCGA-D1-A17Q	UCEC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.2222
p.F529V	DO41903	UCEC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.2222
p.R546K	TCGA-D3-A2JG	SKCM	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.3056
p.R546K	DO47613	SKCM	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.3056
p.E381K	TCGA-EE-A2MR	SKCM	TCGA	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0833
p.E381K	DO37819	SKCM	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0833
p.T544I	TCGA-EO-A22U	UCEC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.5966
p.T544I	DO43755	UCEC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.5966
p.Y530N	TCGA-FS-A4F0	SKCM	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.25
p.Y530N	DO37891	SKCM	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.25
p.P369S	TCGA-GF-A6C9	SKCM	TCGA	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6752
p.P369S	DO51254	SKCM	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6752
p.N357T	TCGA-HU-A4H0	STAD	TCGA	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0556
p.N357T	DO47785	STAD	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0556
p.R363H	TCGA-IB-7889	PAAD	TCGA	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.R363H	DO48310	ESCA	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.R363H	DO46651	PAAD	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.F543L	TCGA-QB-AA9O	SKCM	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.587
p.F543L	DO51267	SKCM	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.587
p.R363C	TCGA-SL-A6JA	UCEC	TCGA	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.R363C	DO219787	UCEC	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.D547E	DO6351	CLLE	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.2778
p.I378V	DO230326	COCA	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1667
p.D372G	DO230347	COCA	ICGC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7198
p.Y530D	DO228210	LICA	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.25
p.D300Y	DO229024	LICA	ICGC	PISST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1111
p.D550V	DO50756	LICA	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.1944
p.M281I	DO27919	ORCA	ICGC	PISST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1389
p.D550Y	DO229224	THCA	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.1944
p.T375R	SIDM01946	Pancreatic Carcinoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.L367F	SIDM00845	Burkitt's Lymphoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.587
p.L367F	ACH-000786	Lymphoma	CCLE	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.587
p.Q371R	SIDM00845	Burkitt's Lymphoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6218
p.Q371R	SIDM00878	Breast Carcinoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6218
p.Q371R	SIDM00793	Burkitt's Lymphoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6218
p.D300N	SIDM00081	Melanoma	GDSC	PISST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1111
p.D300N	ACH-000615	Skin Cancer	CCLE	PISST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1111
p.D300N	SK-MEL-28	skin	COSMIC	PISST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1111
p.P369T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7031
p.P369T	ACH-000945	Lung Cancer	CCLE	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7031
p.P369T	NCI-H650	lung	COSMIC	LGPFQD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7031
p.T544A	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.6028
p.T544A	ACH-000388	Lymphoma	CCLE	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation altering degron motif	0.6028
p.Q527H	SIDM01473	Plasma Cell Myeloma	GDSC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	533:545	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH20

UniProt ID: Q9HBT6

Entrez ID: 28316

Protein name: Cadherin-20

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH20 in