DegronMD

Uniprot ID: Q9HBT6

Source protein: Cadherin-20

Source gene: CDH20

Class: DEG_ODPH_VHL_1

Location: 533:545

E3 ligase: VHL

DEGRON score: 0.9304

ASA_SCORE: 55.6846

COIL: 0.6786

CONS_SCORE: 0.7663

DSS_SCORE: 0.5085

HELIX: 0.0515

FCONS_SCORE: 0.9964

RIG_SCORE: 0.7149

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A537T	TCGA-22-4599	LUSC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.6028
p.A537T	DO26945	LUSC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.6028
p.R554Q	TCGA-66-2754	LUSC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.0833
p.R554Q	DO27612	LUSC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.0833
p.A537S	TCGA-86-A4JF	LUAD	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.6477
p.A537S	DO229015	LICA	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.6477
p.A537S	DO45317	LUAD	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.6477
p.N540S	TCGA-AA-3949	COAD	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.5958
p.N540S	DO7798	COAD	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.5958
p.R524H	TCGA-AJ-A3BG	UCEC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.0833
p.R524H	DO42633	UCEC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.0833
p.A553V	TCGA-AX-A1C4	UCEC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.1111
p.A553V	DO42480	UCEC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.1111
p.F529V	TCGA-D1-A17Q	UCEC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.2222
p.F529V	DO41903	UCEC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.2222
p.R546K	TCGA-D3-A2JG	SKCM	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.3056
p.R546K	DO47613	SKCM	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.3056
p.T544I	TCGA-EO-A22U	UCEC	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.5966
p.T544I	DO43755	UCEC	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.5966
p.Y530N	TCGA-FS-A4F0	SKCM	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.25
p.Y530N	DO37891	SKCM	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.25
p.F543L	TCGA-QB-AA9O	SKCM	TCGA	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.587
p.F543L	DO51267	SKCM	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.587
p.D547E	DO6351	CLLE	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.2778
p.Y530D	DO228210	LICA	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.25
p.D550V	DO50756	LICA	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.1944
p.D550Y	DO229224	THCA	ICGC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.1944
p.T544A	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.6028
p.T544A	ACH-000388	Lymphoma	CCLE	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.6028
p.Q527H	SIDM01473	Plasma Cell Myeloma	GDSC	LAPEAANNPNFTI	DEG_ODPH_VHL_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPEAANNPNFTI

Degron related mutations and impact score

Drug responses associated with CDH20 mutations

All proteins holding degron of LAPEAANNPNFTI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBT6	Cadherin-20	DEG_ODPH_VHL_1	533:545	LAPEAANNPNFTI	VHL	0.9304	More...