DegronMD

Uniprot ID: Q9HBT6

Source protein: Cadherin-20

Source gene: CDH20

Class: LIG_APCC_ABBA_1

Location: 367:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8512

ASA_SCORE: 65

COIL: 0.789

CONS_SCORE: 0.6918

DSS_SCORE: 0.2756

HELIX: 0.0478

FCONS_SCORE: 1.0476

RIG_SCORE: 0.7361

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E361K	TCGA-86-8279	LUAD	TCGA	LGPFQD	LIG_APCC_ABBA_1	0.1667
p.E361K	DO24140	LUAD	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.1667
p.P358T	TCGA-98-8022	LUSC	TCGA	LGPFQD	LIG_APCC_ABBA_1	0.0833
p.P358T	DO26934	LUSC	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.0833
p.P358T	SIDM01768	Melanoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	0.0833
p.P358T	ACH-000899	Skin Cancer	CCLE	LGPFQD	LIG_APCC_ABBA_1	0.0833
p.E361Q	TCGA-AC-A23H	BRCA	TCGA	LGPFQD	LIG_APCC_ABBA_1	0.1667
p.E361Q	DO2401	BRCA	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.1667
p.E381K	TCGA-EE-A2MR	SKCM	TCGA	LGPFQD	LIG_APCC_ABBA_1	0.0833
p.E381K	DO37819	SKCM	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.0833
p.P369S	TCGA-GF-A6C9	SKCM	TCGA	LGPFQD	LIG_APCC_ABBA_1	0.6752
p.P369S	DO51254	SKCM	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.6752
p.N357T	TCGA-HU-A4H0	STAD	TCGA	LGPFQD	LIG_APCC_ABBA_1	0.0556
p.N357T	DO47785	STAD	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.0556
p.R363H	TCGA-IB-7889	PAAD	TCGA	LGPFQD	LIG_APCC_ABBA_1	0.2222
p.R363H	DO48310	ESCA	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.2222
p.R363H	DO46651	PAAD	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.2222
p.R363C	TCGA-SL-A6JA	UCEC	TCGA	LGPFQD	LIG_APCC_ABBA_1	0.2222
p.R363C	DO219787	UCEC	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.2222
p.I378V	DO230326	COCA	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.1667
p.D372G	DO230347	COCA	ICGC	LGPFQD	LIG_APCC_ABBA_1	0.7198
p.T375R	SIDM01946	Pancreatic Carcinoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	0.25
p.L367F	SIDM00845	Burkitt's Lymphoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	0.587
p.L367F	ACH-000786	Lymphoma	CCLE	LGPFQD	LIG_APCC_ABBA_1	0.587
p.Q371R	SIDM00845	Burkitt's Lymphoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	0.6218
p.Q371R	SIDM00878	Breast Carcinoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	0.6218
p.Q371R	SIDM00793	Burkitt's Lymphoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	0.6218
p.P369T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LGPFQD	LIG_APCC_ABBA_1	0.7031
p.P369T	ACH-000945	Lung Cancer	CCLE	LGPFQD	LIG_APCC_ABBA_1	0.7031
p.P369T	NCI-H650	lung	COSMIC	LGPFQD	LIG_APCC_ABBA_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGPFQD

Degron related mutations and impact score

Drug responses associated with CDH20 mutations

All proteins holding degron of LGPFQD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBT6	Cadherin-20	LIG_APCC_ABBA_1	367:372	LGPFQD	APC,CDC20,FZR1	0.8512	More...