DegronMD

Uniprot ID: Q9HBT6

Source protein: Cadherin-20

Source gene: CDH20

Class: DEG_SPOP_SBC_1

Location: 288:292

E3 ligase: SPOP

DEGRON score: 0.5806

ASA_SCORE: 66.8

COIL: 0.7618

CONS_SCORE: 0.7715

DSS_SCORE: 0.2519

HELIX: 0.0098

FCONS_SCORE: 1.0144

RIG_SCORE: 0.7167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D300Y	DO229024	LICA	ICGC	PISST	DEG_SPOP_SBC_1	0.1111
p.M281I	DO27919	ORCA	ICGC	PISST	DEG_SPOP_SBC_1	0.1389
p.D300N	SIDM00081	Melanoma	GDSC	PISST	DEG_SPOP_SBC_1	0.1111
p.D300N	ACH-000615	Skin Cancer	CCLE	PISST	DEG_SPOP_SBC_1	0.1111
p.D300N	SK-MEL-28	skin	COSMIC	PISST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons