DegronMD

Uniprot ID: P26436

Source protein: Acrosomal protein SP-10

Source gene: ACRV1

Class: DEG_SPOP_SBC_1

Location: 178:182

E3 ligase: SPOP

DEGRON score: 0.9783

ASA_SCORE: 71

COIL: 0.7794

CONS_SCORE: 0.653

DSS_SCORE: 0.4709

HELIX: 0.0878

FCONS_SCORE: 1.0637

RIG_SCORE: 0.6332

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A169T	TCGA-AX-A3GB	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	0.0833
p.G185C	TCGA-CK-5916	COAD	TCGA	PISST	DEG_SPOP_SBC_1	0.25
p.G185C	DO8786	COAD	ICGC	PISST	DEG_SPOP_SBC_1	0.25
p.P178Q	TCGA-EE-A183	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	0.7035
p.P178Q	DO37715	SKCM	ICGC	PISST	DEG_SPOP_SBC_1	0.7035
p.E172Q	TCGA-EE-A2MR	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	0.1667
p.G171E	TCGA-EE-A2MR	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	0.1389
p.G171E	KYSE-180	oesophagus	COSMIC	PISST	DEG_SPOP_SBC_1	0.1389
p.A174V	TCGA-HU-A4H5	STAD	TCGA	PISST	DEG_SPOP_SBC_1	0.2222
p.M177I	DO49976	CESC	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.M172V	DO8858	COAD	ICGC	PISST	DEG_SPOP_SBC_1	0.1667
p.R185L	DO16852	KIRC	ICGC	PISST	DEG_SPOP_SBC_1	0.25
p.Q182K	DO229028	LICA	ICGC	PISST	DEG_SPOP_SBC_1	0.6944
p.H177R	DO231096	LUSC	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.I183S	DO46657	PAAD	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T186A	SIDM00189	Melanoma	GDSC	PISST	DEG_SPOP_SBC_1	0.2222
p.T186A	ACH-002098	Skin Cancer	CCLE	PISST	DEG_SPOP_SBC_1	0.2222
p.T186A	CP67-MEL	skin	COSMIC	PISST	DEG_SPOP_SBC_1	0.2222
p.T186I	SIDM01045	Endometrial Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.2222
p.T186I	EN	endometrium	COSMIC	PISST	DEG_SPOP_SBC_1	0.2222
p.N189S	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PISST	DEG_SPOP_SBC_1	0.1389
p.S190Y	HT-115	large_intestine	COSMIC	PISST	DEG_SPOP_SBC_1	0.1111
p.G178E	NCI-H23	lung	COSMIC	PISST	DEG_SPOP_SBC_1	0.7199
p.R187Q	SNU-81	large_intestine	COSMIC	PISST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons