DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 7110:7114

E3 ligase: SPOP

DEGRON score: 0.7163

ASA_SCORE: 94.2

COIL: 0.9336

CONS_SCORE: 0

DSS_SCORE: 0.4819

HELIX: 0.016

FCONS_SCORE: 0

RIG_SCORE: 0.633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L7124V	TCGA-25-1326	OV	TCGA	PISST	DEG_SPOP_SBC_1	0.0556
p.L7124V	DO28154	OV	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.P7110H	TCGA-CM-6165	COAD	TCGA	PISST	DEG_SPOP_SBC_1	0.7694
p.P7110H	DO9900	COAD	ICGC	PISST	DEG_SPOP_SBC_1	0.7694
p.L7124F	TCGA-CR-6472	HNSC	TCGA	PISST	DEG_SPOP_SBC_1	0.0556
p.L7124F	DO15870	HNSC	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.P7109S	TCGA-EE-A182	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	0.3056
p.P7109S	DO37814	SKCM	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.S7112P	DO48219	ESCA	ICGC	PISST	DEG_SPOP_SBC_1	0.6752
p.S7112F	DO220875	MELA	ICGC	PISST	DEG_SPOP_SBC_1	0.7982
p.S7120F	DO220891	MELA	ICGC	PISST	DEG_SPOP_SBC_1	0.1667
p.S7120F	DO219878	SKCA	ICGC	PISST	DEG_SPOP_SBC_1	0.1667
p.T7114A	SIDM01156	Small Cell Lung Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.7139
p.T7114A	ACH-000890	Lung Cancer	CCLE	PISST	DEG_SPOP_SBC_1	0.7139
p.T7114A	SW1271	lung	COSMIC	PISST	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons