DegronMD

Uniprot ID: Q9H5Z6

Source protein: Protein FAM124B

Source gene: FAM124B

Class: DEG_SPOP_SBC_1

Location: 225:229

E3 ligase: SPOP

DEGRON score: 0.5377

ASA_SCORE: 70.68

COIL: 0.5758

CONS_SCORE: 0.6236

DSS_SCORE: 0.3902

HELIX: 0.009

FCONS_SCORE: 0.8726

RIG_SCORE: 0.7632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M224T	TCGA-77-A5G3	LUSC	TCGA	PISST	DEG_SPOP_SBC_1	0.3056
p.M224T	DO45456	LUSC	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.P222Q	TCGA-86-A4JF	LUAD	TCGA	PISST	DEG_SPOP_SBC_1	0.25
p.P222Q	DO45317	LUAD	ICGC	PISST	DEG_SPOP_SBC_1	0.25
p.P217H	TCGA-BR-6566	STAD	TCGA	PISST	DEG_SPOP_SBC_1	0.1111
p.P217H	DO38217	STAD	ICGC	PISST	DEG_SPOP_SBC_1	0.1111
p.P222L	TCGA-D3-A8GI	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	0.25
p.P222L	DO50284	SKCM	ICGC	PISST	DEG_SPOP_SBC_1	0.25
p.Q234L	DO231963	LICA	ICGC	PISST	DEG_SPOP_SBC_1	0.1944
p.P222S	DO222843	MELA	ICGC	PISST	DEG_SPOP_SBC_1	0.25
p.P225S	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.6752
p.P225S	ACH-000015	Lung Cancer	CCLE	PISST	DEG_SPOP_SBC_1	0.6752
p.P225S	NCI-H1581	lung	COSMIC	PISST	DEG_SPOP_SBC_1	0.6752
p.S227R	SIDM00014	Colorectal Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.7427
p.S227R	LIM1215	large_intestine	COSMIC	PISST	DEG_SPOP_SBC_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons