DegronMD - P26436(ACRV1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A169T	TCGA-AX-A3GB	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0833
p.G185C	TCGA-CK-5916	COAD	TCGA	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.25
p.G185C	DO8786	COAD	ICGC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.25
p.P178Q	TCGA-EE-A183	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7035
p.P178Q	DO37715	SKCM	ICGC	PISST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7035
p.E172Q	TCGA-EE-A2MR	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1667
p.G171E	TCGA-EE-A2MR	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1389
p.G171E	KYSE-180	oesophagus	COSMIC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1389
p.A174V	TCGA-HU-A4H5	STAD	TCGA	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.2222
p.M177I	DO49976	CESC	ICGC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.M172V	DO8858	COAD	ICGC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1667
p.R185L	DO16852	KIRC	ICGC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.25
p.Q182K	DO229028	LICA	ICGC	PISST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.6944
p.H177R	DO231096	LUSC	ICGC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.I183S	DO46657	PAAD	ICGC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.T186A	SIDM00189	Melanoma	GDSC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.2222
p.T186A	ACH-002098	Skin Cancer	CCLE	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.2222
p.T186A	CP67-MEL	skin	COSMIC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.2222
p.T186I	SIDM01045	Endometrial Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.2222
p.T186I	EN	endometrium	COSMIC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.2222
p.N189S	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1389
p.S190Y	HT-115	large intestine	COSMIC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1111
p.G178E	NCI-H23	lung	COSMIC	PISST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7199
p.R187Q	SNU-81	large intestine	COSMIC	PISST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACRV1

UniProt ID: P26436

Entrez ID: 56

Protein name: Acrosomal protein SP-10 (Acrosomal vesicle protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACRV1 in