DegronMD - Q9H5Z6(FAM124B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M224T	TCGA-77-A5G3	LUSC	TCGA	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.3056
p.M224T	DO45456	LUSC	ICGC	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.3056
p.P222Q	TCGA-86-A4JF	LUAD	TCGA	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.25
p.P222Q	DO45317	LUAD	ICGC	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.25
p.P217H	TCGA-BR-6566	STAD	TCGA	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1111
p.P217H	DO38217	STAD	ICGC	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1111
p.P222L	TCGA-D3-A8GI	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.25
p.P222L	DO50284	SKCM	ICGC	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.25
p.Q234L	DO231963	LICA	ICGC	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1944
p.P222S	DO222843	MELA	ICGC	PISST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.25
p.P225S	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.6752
p.P225S	ACH-000015	Lung Cancer	CCLE	PISST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.6752
p.P225S	NCI-H1581	lung	COSMIC	PISST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.6752
p.S227R	SIDM00014	Colorectal Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7427
p.S227R	LIM1215	large intestine	COSMIC	PISST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7427

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons