DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1808:1812

E3 ligase: SPOP

DEGRON score: 0.6975

ASA_SCORE: 89.96

COIL: 0.9056

CONS_SCORE: 0.3274

DSS_SCORE: 0.6885

HELIX: 0.0156

FCONS_SCORE: 1.1144

RIG_SCORE: 0.6227

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1813R	TCGA-13-1405	OV	TCGA	PISST	DEG_SPOP_SBC_1	0.3056
p.G1813R	DO28012	OV	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.S1811Y	TCGA-85-8354	LUSC	TCGA	PISST	DEG_SPOP_SBC_1	0.712
p.S1811Y	DO45467	LUSC	ICGC	PISST	DEG_SPOP_SBC_1	0.712
p.P1808S	TCGA-AC-A23H	BRCA	TCGA	PISST	DEG_SPOP_SBC_1	0.6752
p.P1808S	DO2401	BRCA	ICGC	PISST	DEG_SPOP_SBC_1	0.6752
p.T1804A	TCGA-BS-A0UF	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	0.2222
p.T1804A	DO41488	UCEC	ICGC	PISST	DEG_SPOP_SBC_1	0.2222
p.P1814H	TCGA-EA-A3HU	CESC	TCGA	PISST	DEG_SPOP_SBC_1	0.2778
p.P1814H	DO6320	CESC	ICGC	PISST	DEG_SPOP_SBC_1	0.2778
p.T1816P	TCGA-EE-A29B	SKCM	TCGA	PISST	DEG_SPOP_SBC_1	0.2222
p.T1816P	DO47255	SKCM	ICGC	PISST	DEG_SPOP_SBC_1	0.2222
p.P1808T	TCGA-EO-A22X	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	0.7031
p.P1808T	DO43907	UCEC	ICGC	PISST	DEG_SPOP_SBC_1	0.7031
p.P1814A	TCGA-KQ-A41R	BLCA	TCGA	PISST	DEG_SPOP_SBC_1	0.2778
p.P1814A	DO223592	BLCA	ICGC	PISST	DEG_SPOP_SBC_1	0.2778
p.Q1821K	TCGA-VQ-A8PT	STAD	TCGA	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821K	DO51776	STAD	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO48367	BLCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO48370	BLCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO48407	BLCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO224674	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO224786	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO229010	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO229013	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO229016	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO229003	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.Q1821H	DO229005	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0833
p.T1807S	DO48360	BLCA	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T1807S	DO222760	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T1807S	DO222839	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T1807S	DO50980	LAML	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T1807S	DO51021	LAML	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T1807S	DO51025	LAML	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T1807S	DO52372	LUSC	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T1822A	DO48417	BLCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822A	DO48407	BLCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822A	DO224786	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822A	DO229010	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822A	DO229013	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822A	DO229016	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822A	DO229003	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822A	DO229005	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.0556
p.G1813A	DO222737	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.3056
p.T1806S	DO229010	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.2778
p.T1806S	DO229013	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.2778
p.T1806S	DO229016	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.2778
p.T1806S	DO229003	COCA	ICGC	PISST	DEG_SPOP_SBC_1	0.2778
p.T1822S	SIDM00331	B-Lymphoblastic Leukemia	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822S	SIDM00995	Other Solid Cancers	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.T1822S	SIDM00816	Kidney Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.0556
p.S1810C	SIDM01878	Non-Cancerous	GDSC	PISST	DEG_SPOP_SBC_1	0.7541
p.S1810C	SIDM00778	Colorectal Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.7541
p.S1810C	NCI-H747	large_intestine	COSMIC	PISST	DEG_SPOP_SBC_1	0.7541
p.P1803H	SIDM00980	Gastric Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.1944
p.A1817T	SW872	soft_tissue	COSMIC	PISST	DEG_SPOP_SBC_1	0.1944
p.G1813D	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	PISST	DEG_SPOP_SBC_1	0.3056
p.G1813D	HCC1569	breast	COSMIC	PISST	DEG_SPOP_SBC_1	0.3056
p.G1813D	SK-GT-2	stomach	COSMIC	PISST	DEG_SPOP_SBC_1	0.3056
p.P1802S	SW837	large_intestine	COSMIC	PISST	DEG_SPOP_SBC_1	0.1667
p.H1800R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PISST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISST

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of PISST