DegronMD

Uniprot ID: Q08050

Source protein: Forkhead box protein M1

Source gene: FOXM1

Class: DEG_SPOP_SBC_1

Location: 607:611

E3 ligase: SPOP

DEGRON score: 0.9828

ASA_SCORE: 84.28

COIL: 0.8922

CONS_SCORE: 0.5026

DSS_SCORE: 0.5357

HELIX: 0.0134

FCONS_SCORE: 1.0363

RIG_SCORE: 0.682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S620F	TCGA-73-4658	LUAD	TCGA	PISST	DEG_SPOP_SBC_1	0.5278
p.S620F	DO23663	LUAD	ICGC	PISST	DEG_SPOP_SBC_1	0.5278
p.A611T	TCGA-AA-3715	COAD	TCGA	PISST	DEG_SPOP_SBC_1	0.7139
p.A611T	TCGA-AJ-A3BG	UCEC	TCGA	PISST	DEG_SPOP_SBC_1	0.7139
p.A611T	DO8018	COAD	ICGC	PISST	DEG_SPOP_SBC_1	0.7139
p.A611T	DO233652	GACA	ICGC	PISST	DEG_SPOP_SBC_1	0.7139
p.A611T	DO42633	UCEC	ICGC	PISST	DEG_SPOP_SBC_1	0.7139
p.A611T	SIDM00619	Thyroid Gland Carcinoma	GDSC	PISST	DEG_SPOP_SBC_1	0.7139
p.A611T	KMH-2	thyroid	COSMIC	PISST	DEG_SPOP_SBC_1	0.7139
p.S619C	TCGA-XF-A9SI	BLCA	TCGA	PISST	DEG_SPOP_SBC_1	0.1111
p.S619C	DO51914	BLCA	ICGC	PISST	DEG_SPOP_SBC_1	0.1111
p.P606T	ACH-000967	Colon/Colorectal Cancer	CCLE	PISST	DEG_SPOP_SBC_1	0.3056
p.W609C	ACH-001413	Bladder Cancer	CCLE	PISST	DEG_SPOP_SBC_1	0.7
p.P618L	MCC13	skin	COSMIC	PISST	DEG_SPOP_SBC_1	0.1389
p.P618S	MCC13	skin	COSMIC	PISST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26436	Acrosomal protein SP-10	DEG_SPOP_SBC_1	178:182	PISST	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2808:2812	PISST	SPOP	0.8491	More...
Q08050	Forkhead box protein M1	DEG_SPOP_SBC_1	607:611	PISST	SPOP	0.9828	More...
Q08AE8	Protein spire homolog 1	DEG_SPOP_SBC_1	505:509	PISST	SPOP	0.9941	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1808:1812	PISST	SPOP	0.6975	More...
Q8IW35	Centrosomal protein of 97 kDa	DEG_SPOP_SBC_1	655:659	PISST	SPOP	0.9197	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7110:7114	PISST	SPOP	0.7163	More...
Q99935	Opiorphin prepropeptide	DEG_SPOP_SBC_1	181:185	PISST	SPOP	0.9979	More...
Q9H5Z6	Protein FAM124B	DEG_SPOP_SBC_1	225:229	PISST	SPOP	0.5377	More...
Q9HBT6	Cadherin-20	DEG_SPOP_SBC_1	288:292	PISST	SPOP	0.5806	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	96:100	PISST	SPOP	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons