DegronMD

Uniprot ID: Q08AE8

Source protein: Protein spire homolog 1

Source gene: SPIRE1

Class: DEG_SCF_FBW7_2

Location: 506:513

E3 ligase: FBXW7

DEGRON score: 0.9633

ASA_SCORE: 93.0125

COIL: 0.9094

CONS_SCORE: 0.3833

DSS_SCORE: 0.8329

HELIX: 0.0724

FCONS_SCORE: 0.975

RIG_SCORE: 0.5909

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T509I	TCGA-QC-A7B5	SARC	TCGA	ISSTPQPE	DEG_SCF_FBW7_2	0.8189
p.T509I	DO220239	SARC	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	0.8189
p.T509S	TCGA-QC-A7B5	SARC	TCGA	ISSTPQPE	DEG_SCF_FBW7_2	0.8227
p.T509S	DO220239	SARC	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	0.8227
p.P517T	DO229034	LICA	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	0.2222
p.P517S	DO229229	THCA	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	0.2222
p.P500S	DO229232	THCA	ICGC	ISSTPQPE	DEG_SCF_FBW7_2	0.1667
p.P510S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ISSTPQPE	DEG_SCF_FBW7_2	0.6752
p.P498L	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	ISSTPQPE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08AE8	Protein spire homolog 1	DEG_SCF_FBW7_2	506:513	ISSTPQPE	FBXW7	0.9633	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons