DegronMD

Uniprot ID: Q08AE8

Source protein: Protein spire homolog 1

Source gene: SPIRE1

Class: DEG_SCF_FBW7_1

Location: 412:418

E3 ligase: FBXW7

DEGRON score: 0.9954

ASA_SCORE: 71.1429

COIL: 0.8069

CONS_SCORE: 0.3228

DSS_SCORE: 0.4542

HELIX: 0.1416

FCONS_SCORE: 1.1104

RIG_SCORE: 0.7058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L421F	TCGA-62-A46O	LUAD	TCGA	VTTPEST	DEG_SCF_FBW7_1	0.25
p.L421F	DO26240	LUAD	ICGC	VTTPEST	DEG_SCF_FBW7_1	0.25
p.L421F	SIDM00193	Colorectal Carcinoma	GDSC	VTTPEST	DEG_SCF_FBW7_1	0.25
p.L421F	ACH-000991	Colon/Colorectal Cancer	CCLE	VTTPEST	DEG_SCF_FBW7_1	0.25
p.L421F	SNU-81	large_intestine	COSMIC	VTTPEST	DEG_SCF_FBW7_1	0.25
p.L421I	TCGA-AP-A1DV	UCEC	TCGA	VTTPEST	DEG_SCF_FBW7_1	0.25
p.L421I	DO43186	UCEC	ICGC	VTTPEST	DEG_SCF_FBW7_1	0.25
p.K419N	TCGA-AP-A1E0	UCEC	TCGA	VTTPEST	DEG_SCF_FBW7_1	0.3056
p.K419N	DO43154	UCEC	ICGC	VTTPEST	DEG_SCF_FBW7_1	0.3056
p.F407L	TCGA-B5-A11N	UCEC	TCGA	VTTPEST	DEG_SCF_FBW7_1	0.1944
p.F407L	DO41458	UCEC	ICGC	VTTPEST	DEG_SCF_FBW7_1	0.1944
p.M426V	TCGA-BT-A2LA	BLCA	TCGA	VTTPEST	DEG_SCF_FBW7_1	0.1111
p.M426V	DO561	BLCA	ICGC	VTTPEST	DEG_SCF_FBW7_1	0.1111
p.Y405C	DO228850	LICA	ICGC	VTTPEST	DEG_SCF_FBW7_1	0.1389
p.V427A	ACH-000978	Endometrial/Uterine Cancer	CCLE	VTTPEST	DEG_SCF_FBW7_1	0.0833
p.V427A	EN	endometrium	COSMIC	VTTPEST	DEG_SCF_FBW7_1	0.0833
p.P415R	ACH-001677	Lymphoma	CCLE	VTTPEST	DEG_SCF_FBW7_1	0.7512
p.E420K	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPEST	DEG_SCF_FBW7_1	0.2778
p.Q420R	SISO	cervix	COSMIC	VTTPEST	DEG_SCF_FBW7_1	0.2778
p.P421L	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPEST	DEG_SCF_FBW7_1	0.25
p.L407F	SNU-81	large_intestine	COSMIC	VTTPEST	DEG_SCF_FBW7_1	0.1944
p.V413A	EN	endometrium	COSMIC	VTTPEST	DEG_SCF_FBW7_1	0.6936
p.R410H	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPEST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08AE8	Protein spire homolog 1	DEG_SCF_FBW7_1	412:418	VTTPEST	FBXW7	0.9954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons