DegronMD

Uniprot ID: Q08AE8

Source protein: Protein spire homolog 1

Source gene: SPIRE1

Class: DEG_APCC_KENBOX_2

Location: 241:245

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9537

ASA_SCORE: 97.38

COIL: 0.408

CONS_SCORE: 0.609

DSS_SCORE: 0.3125

HELIX: 0.5984

FCONS_SCORE: 1.2869

RIG_SCORE: 0.7682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K239N	TCGA-DD-AAE7	LIHC	TCGA	AKENL	DEG_APCC_KENBOX_2	0.2778
p.K239N	DO52262	LIHC	ICGC	AKENL	DEG_APCC_KENBOX_2	0.2778
p.A241V	TCGA-E6-A1LX	UCEC	TCGA	AKENL	DEG_APCC_KENBOX_2	0.5825
p.A241V	DO41020	UCEC	ICGC	AKENL	DEG_APCC_KENBOX_2	0.5825
p.Q249K	TCGA-ND-A4WC	UCS	TCGA	AKENL	DEG_APCC_KENBOX_2	0.2222
p.D255G	SIDM00537	Colorectal Carcinoma	GDSC	AKENL	DEG_APCC_KENBOX_2	0.0556
p.D255G	ACH-000982	Colon/Colorectal Cancer	CCLE	AKENL	DEG_APCC_KENBOX_2	0.0556
p.D255G	ACH-001345	Colon/Colorectal Cancer	CCLE	AKENL	DEG_APCC_KENBOX_2	0.0556
p.D255G	GP5d	large_intestine	COSMIC	AKENL	DEG_APCC_KENBOX_2	0.0556
p.K246N	SIDM00920	Breast Carcinoma	GDSC	AKENL	DEG_APCC_KENBOX_2	0.3056
p.K246N	ACH-000783	Breast Cancer	CCLE	AKENL	DEG_APCC_KENBOX_2	0.3056
p.K246N	CAMA-1	breast	COSMIC	AKENL	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75717	WD repeat and HMG-box DNA-binding protein 1	DEG_APCC_KENBOX_2	1100:1104	AKENL	APC,CDC20,FZR1	0.5096	More...
Q08AE8	Protein spire homolog 1	DEG_APCC_KENBOX_2	241:245	AKENL	APC,CDC20,FZR1	0.9537	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons