DegronMD

Uniprot ID: O75717

Source protein: WD repeat and HMG-box DNA-binding protein 1

Source gene: WDHD1

Class: DEG_APCC_KENBOX_2

Location: 1100:1104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5096

ASA_SCORE: 104.74

COIL: 0.338

CONS_SCORE: 0.2685

DSS_SCORE: 0.6193

HELIX: 0.659

FCONS_SCORE: 0.9992

RIG_SCORE: 0.7259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1099R	TCGA-34-5928	LUSC	TCGA	AKENL	DEG_APCC_KENBOX_2	0.3056
p.Q1096H	TCGA-B5-A3FA	UCEC	TCGA	AKENL	DEG_APCC_KENBOX_2	0.2222
p.K1108Q	TCGA-BH-A0WA	BRCA	TCGA	AKENL	DEG_APCC_KENBOX_2	0.3333
p.E1102D	TCGA-EO-A22X	UCEC	TCGA	AKENL	DEG_APCC_KENBOX_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75717	WD repeat and HMG-box DNA-binding protein 1	DEG_APCC_KENBOX_2	1100:1104	AKENL	APC,CDC20,FZR1	0.5096	More...
Q08AE8	Protein spire homolog 1	DEG_APCC_KENBOX_2	241:245	AKENL	APC,CDC20,FZR1	0.9537	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons