DegronMD

Uniprot ID: Q08AE8

Source protein: Protein spire homolog 1

Source gene: SPIRE1

Class: DEG_APCC_KENBOX_2

Location: 435:439

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9955

ASA_SCORE: 96.22

COIL: 0.7572

CONS_SCORE: 0.3457

DSS_SCORE: 0.626

HELIX: 0.1962

FCONS_SCORE: 1.0923

RIG_SCORE: 0.6641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G430S	TCGA-66-2758	LUSC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.1944
p.G430S	DO26731	LUSC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1944
p.Q444H	TCGA-AJ-A5DW	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.1944
p.Q444H	DO50075	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1944
p.M426V	TCGA-BT-A2LA	BLCA	TCGA	TKENG	DEG_APCC_KENBOX_2	0.0833
p.M426V	DO561	BLCA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.0833
p.G430C	TCGA-D3-A2JC	SKCM	TCGA	TKENG	DEG_APCC_KENBOX_2	0.1944
p.G430C	DO47578	SKCM	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1944
p.Q445K	DO225357	BRCA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1667
p.N448K	DO229009	LICA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.0833
p.P447L	DO27907	ORCA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1111
p.N438S	DO232761	PBCA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.7069
p.Q434R	SIDM00394	Cervical Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	0.3056
p.Q434R	ACH-001650	Cervical Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	0.3056
p.Q434R	SISO	cervix	COSMIC	TKENG	DEG_APCC_KENBOX_2	0.3056
p.V427A	ACH-000978	Endometrial/Uterine Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	0.1111
p.V427A	EN	endometrium	COSMIC	TKENG	DEG_APCC_KENBOX_2	0.1111
p.Y444C	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	TKENG	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_APCC_KENBOX_2	70:74	TKENG	APC,CDC20,FZR1	0.9942	More...
Q08AE8	Protein spire homolog 1	DEG_APCC_KENBOX_2	435:439	TKENG	APC,CDC20,FZR1	0.9955	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_APCC_KENBOX_2	360:364	TKENG	APC,CDC20,FZR1	0.6934	More...
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	DEG_APCC_KENBOX_2	807:811	TKENG	APC,CDC20,FZR1	0.9898	More...
Q9HD67	Unconventional myosin-X	DEG_APCC_KENBOX_2	1274:1278	TKENG	APC,CDC20,FZR1	0.9258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons