DegronMD

Uniprot ID: Q9HD67

Source protein: Unconventional myosin-X

Source gene: MYO10

Class: DEG_APCC_KENBOX_2

Location: 1274:1278

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9258

ASA_SCORE: 82.56

COIL: 0.7796

CONS_SCORE: 0.5796

DSS_SCORE: 0.2858

HELIX: 0.0748

FCONS_SCORE: 1.1669

RIG_SCORE: 0.8022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1285Y	TCGA-46-3769	LUSC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.1389
p.T1265M	TCGA-B5-A3FC	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.0833
p.D1285V	TCGA-CC-A8HS	LIHC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.1389
p.D1285V	DO52186	LIHC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1389
p.D1280N	TCGA-DU-6392	LGG	TCGA	TKENG	DEG_APCC_KENBOX_2	0.2778
p.R1264Q	TCGA-FI-A2D0	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	0.0556
p.G1278E	TCGA-HT-A619	LGG	TCGA	TKENG	DEG_APCC_KENBOX_2	0.6087
p.W1269C	DO2819	BRCA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1944
p.N1274K	DO52064	HNSC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.6918
p.M1268I	DO27628	LUSC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1667
p.E1268G	DO232855	NACA	ICGC	TKENG	DEG_APCC_KENBOX_2	0.1667
p.A1277D	DO42504	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	0.7793
p.T1271I	MCC13	skin	COSMIC	TKENG	DEG_APCC_KENBOX_2	0.25
p.V1272I	QGP-1	pancreas	COSMIC	TKENG	DEG_APCC_KENBOX_2	0.2778
p.I1264S	COLO-680N	oesophagus	COSMIC	TKENG	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11137	Microtubule-associated protein 2	DEG_APCC_KENBOX_2	70:74	TKENG	APC,CDC20,FZR1	0.9942	More...
Q08AE8	Protein spire homolog 1	DEG_APCC_KENBOX_2	435:439	TKENG	APC,CDC20,FZR1	0.9955	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_APCC_KENBOX_2	360:364	TKENG	APC,CDC20,FZR1	0.6934	More...
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	DEG_APCC_KENBOX_2	807:811	TKENG	APC,CDC20,FZR1	0.9898	More...
Q9HD67	Unconventional myosin-X	DEG_APCC_KENBOX_2	1274:1278	TKENG	APC,CDC20,FZR1	0.9258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons