DegronMD - Q9HD67(MYO10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1120E	TCGA-44-6774	LUAD	TCGA	DYR	CBL_MET	1120:1122	Mutation altering degron motif	0.6758
p.D1120E	DO25000	LUAD	ICGC	DYR	CBL_MET	1120:1122	Mutation altering degron motif	0.6758
p.D1285Y	TCGA-46-3769	LUSC	TCGA	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.1389
p.G1080V	TCGA-55-6969	LUAD	TCGA	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0556
p.G1080V	DO24586	LUAD	ICGC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0556
p.S1131L	TCGA-AX-A2HC	UCEC	TCGA	DYR	CBL_MET	1120:1122	Mutation blocking phosphorylation signal	0.5278
p.L1063P	TCGA-B5-A1MW	UCEC	TCGA	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.2778
p.L1063P	DO42913	UCEC	ICGC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.2778
p.T1265M	TCGA-B5-A3FC	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.0833
p.S1062R	TCGA-BG-A2L7	UCEC	TCGA	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.25
p.S1062R	DO42344	UCEC	ICGC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.25
p.D1285V	TCGA-CC-A8HS	LIHC	TCGA	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.1389
p.D1285V	DO52186	LIHC	ICGC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.1389
p.R1122C	TCGA-DD-A73D	LIHC	TCGA	DYR	CBL_MET	1120:1122	Mutation altering degron motif	0.8301
p.D1280N	TCGA-DU-6392	LGG	TCGA	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.2778
p.R1264Q	TCGA-FI-A2D0	UCEC	TCGA	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.0556
p.G1069S	TCGA-FI-A2D5	UCEC	TCGA	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation altering degron motif	0.6993
p.G1069S	DO41331	UCEC	ICGC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation altering degron motif	0.6993
p.G1278E	TCGA-HT-A619	LGG	TCGA	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation altering degron motif	0.6087
p.R1115P	DO51900	BLCA	ICGC	DYR	CBL_MET	1120:1122	Mutation rewiring degron network	0.1944
p.W1269C	DO2819	BRCA	ICGC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.1944
p.E1070K	DO234353	ESAD	ICGC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation altering degron motif	0.7022
p.N1274K	DO52064	HNSC	ICGC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation altering degron motif	0.6918
p.T1058A	DO23543	LIRI	ICGC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.1389
p.D1120Y	DO25000	LUAD	ICGC	DYR	CBL_MET	1120:1122	Mutation altering degron motif	0.7325
p.M1268I	DO27628	LUSC	ICGC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.1667
p.S1066F	DO222753	MELA	ICGC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation altering degron motif	0.6871
p.E1268G	DO232855	NACA	ICGC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.1667
p.V1118I	DO41235	UCEC	ICGC	DYR	CBL_MET	1120:1122	Mutation blocking phosphorylation signal	0.7222
p.A1277D	DO42504	UCEC	ICGC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation altering degron motif	0.7793
p.Y1113C	SIDM00371	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	1120:1122	Mutation rewiring degron network	0.1389
p.Y1113C	ACH-000652	Pancreatic Cancer	CCLE	DYR	CBL_MET	1120:1122	Mutation rewiring degron network	0.1389
p.Y1113C	SUIT-2	pancreas	COSMIC	DYR	CBL_MET	1120:1122	Mutation rewiring degron network	0.1389
p.A1079S	SIDM00286	Neuroblastoma	GDSC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0833
p.A1079S	ACH-000136	Neuroblastoma	CCLE	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0833
p.A1079S	CHP-126	autonomic ganglia	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0833
p.P1055A	SIDM01185	Other Solid Cancers	GDSC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0556
p.P1055A	ACH-002204	Bone Cancer	CCLE	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0556
p.P1055A	U-CH2	bone	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0556
p.N1111K	ACH-000248	Breast Cancer	CCLE	DYR	CBL_MET	1120:1122	Mutation rewiring degron network	0.0833
p.T1271I	MCC13	skin	COSMIC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.25
p.A1073T	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.25
p.V1272I	QGP-1	pancreas	COSMIC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.2778
p.Y1124C	SUIT-2	pancreas	COSMIC	DYR	CBL_MET	1120:1122	Mutation blocking phosphorylation signal	0.7222
p.P1066A	U-CH2	bone	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation altering degron motif	0.7503
p.P1056L	IPC-298	skin	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	1065:1070	Mutation rewiring degron network	0.0833
p.I1264S	COLO-680N	oesophagus	COSMIC	TKENG	DEG_APCC_KENBOX_2	1274:1278	Mutation rewiring degron network	0.0556

Kaplan plot for MYO10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO10

UniProt ID: Q9HD67

Entrez ID: 4651

Protein name: Unconventional myosin-X (Unconventional myosin-10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYO10 in