DegronMD

Uniprot ID: Q9HD67

Source protein: Unconventional myosin-X

Source gene: MYO10

Class: DEG_Kelch_Keap1_1

Location: 1065:1070

E3 ligase: KEAP1

DEGRON score: 0.8551

ASA_SCORE: 84.3833

COIL: 0.8913

CONS_SCORE: 0.3444

DSS_SCORE: 0.6047

HELIX: 0.072

FCONS_SCORE: 1.1429

RIG_SCORE: 0.5593

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1066A	U-CH2	bone	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	0.7503
p.E1070K	DO234353	ESAD	ICGC	NSSSGE	DEG_Kelch_Keap1_1	0.7022
p.G1069S	TCGA-FI-A2D5	UCEC	TCGA	NSSSGE	DEG_Kelch_Keap1_1	0.6993
p.G1069S	DO41331	UCEC	ICGC	NSSSGE	DEG_Kelch_Keap1_1	0.6993
p.S1066F	DO222753	MELA	ICGC	NSSSGE	DEG_Kelch_Keap1_1	0.6871
p.L1063P	TCGA-B5-A1MW	UCEC	TCGA	NSSSGE	DEG_Kelch_Keap1_1	0.2778
p.L1063P	DO42913	UCEC	ICGC	NSSSGE	DEG_Kelch_Keap1_1	0.2778
p.S1062R	TCGA-BG-A2L7	UCEC	TCGA	NSSSGE	DEG_Kelch_Keap1_1	0.25
p.S1062R	DO42344	UCEC	ICGC	NSSSGE	DEG_Kelch_Keap1_1	0.25
p.A1073T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	0.25
p.T1058A	DO23543	LIRI	ICGC	NSSSGE	DEG_Kelch_Keap1_1	0.1389
p.A1079S	SIDM00286	Neuroblastoma	GDSC	NSSSGE	DEG_Kelch_Keap1_1	0.0833
p.A1079S	ACH-000136	Neuroblastoma	CCLE	NSSSGE	DEG_Kelch_Keap1_1	0.0833
p.A1079S	CHP-126	autonomic_ganglia	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	0.0833
p.P1056L	IPC-298	skin	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	0.0833
p.G1080V	TCGA-55-6969	LUAD	TCGA	NSSSGE	DEG_Kelch_Keap1_1	0.0556
p.G1080V	DO24586	LUAD	ICGC	NSSSGE	DEG_Kelch_Keap1_1	0.0556
p.P1055A	SIDM01185	Other Solid Cancers	GDSC	NSSSGE	DEG_Kelch_Keap1_1	0.0556
p.P1055A	ACH-002204	Bone Cancer	CCLE	NSSSGE	DEG_Kelch_Keap1_1	0.0556
p.P1055A	U-CH2	bone	COSMIC	NSSSGE	DEG_Kelch_Keap1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HD67	Unconventional myosin-X	DEG_Kelch_Keap1_1	1065:1070	NSSSGE	KEAP1	0.8551	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons