DegronMD - Q8TEK3(DOT1L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G821A	TCGA-46-3768	LUSC	TCGA	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.0556
p.G821A	DO26466	LUSC	ICGC	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.0556
p.A1114V	TCGA-86-A4JF	LUAD	TCGA	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5825
p.A1114V	DO45317	LUAD	ICGC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5825
p.G811S	TCGA-AA-3524	COAD	TCGA	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation altering degron motif	0.5882
p.G811S	DO8011	COAD	ICGC	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation altering degron motif	0.5882
p.S802L	TCGA-AA-A010	COAD	TCGA	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1944
p.P758L	TCGA-CV-7568	HNSC	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.6471
p.P758L	DO14160	HNSC	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.6471
p.P813L	TCGA-DD-AAW1	LIHC	TCGA	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2778
p.P813L	DO219577	LIHC	ICGC	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2778
p.P813L	SIDM00166	Other Solid Cancers	GDSC	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2778
p.P813L	ACH-000302	Endometrial/Uterine Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2778
p.P962S	TCGA-DS-A1OB	CESC	TCGA	LTPGAE	DEG_SCF_FBW7_2	956:961	Mutation rewiring degron network	0.3056
p.P962S	DO6323	CESC	ICGC	LTPGAE	DEG_SCF_FBW7_2	956:961	Mutation rewiring degron network	0.3056
p.A768T	TCGA-DU-6392	LGG	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.2222
p.A768T	DO22237	LGG	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.2222
p.P1105L	TCGA-E5-A4TZ	BLCA	TCGA	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.3056
p.P1105L	DO44055	BLCA	ICGC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.3056
p.P1124H	TCGA-FS-A1ZP	SKCM	TCGA	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.0556
p.P1124H	DO37703	SKCM	ICGC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.0556
p.R759C	TCGA-MX-A5UJ	STAD	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.719
p.R759C	DO48547	STAD	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.719
p.R759C	SIDM01609	Endometrial Carcinoma	GDSC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.719
p.R759C	ACH-000972	Endometrial/Uterine Cancer	CCLE	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.719
p.P820H	DO222574	BTCA	ICGC	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.0833
p.V755I	DO230334	COCA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.3056
p.A797V	DO233731	GACA	ICGC	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.0556
p.L763R	DO229051	LICA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.8428
p.S1112F	DO222434	MELA	ICGC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.6871
p.P758Q	DO232863	NACA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation altering degron motif	0.5924
p.A767V	DO232761	PBCA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.25
p.A950T	DO229248	THCA	ICGC	LTPGAE	DEG_SCF_FBW7_2	956:961	Mutation rewiring degron network	0.1667
p.P752S	SIDM01104	Melanoma	GDSC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.2222
p.P752S	ACH-000640	Skin Cancer	CCLE	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.2222
p.P752S	SK-MEL-31	skin	COSMIC	GRPRLEKLS	DEG_APCC_DBOX_1	756:764	Mutation rewiring degron network	0.2222
p.A1109V	SIDM00007	Other Solid Cancers	GDSC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5825
p.A1109V	ACH-001550	Skin Cancer	CCLE	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5825
p.A1109V	MCC13	skin	COSMIC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5825
p.P1120S	SIDM00068	Colorectal Carcinoma	GDSC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1667
p.P1120S	ACH-002394	Colon/Colorectal Cancer	CCLE	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1667
p.P1120S	GEO	large intestine	COSMIC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1667
p.L812P	SIDM01343	Gastric Carcinoma	GDSC	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.3056
p.L812P	ACH-000764	Gastric Cancer	CCLE	TKENG	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.3056
p.S1121L	SIDM01750	Melanoma	GDSC	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1389
p.S1121L	ACH-000801	Skin Cancer	CCLE	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1389
p.Q1119H	ACH-001441	Eye Cancer	CCLE	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1944
p.Q1119H	ACH-001520	Leukemia	CCLE	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1944
p.T1118K	ACH-002163	Breast Cancer	CCLE	KRRALPSVA	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.2222

Kaplan plot for DOT1L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOT1L

UniProt ID: Q8TEK3

Entrez ID: 84444

Protein name: Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOT1L in