DegronMD

Uniprot ID: Q8TEK3

Source protein: Histone-lysine N-methyltransferase, H3 lysine-79 specific

Source gene: DOT1L

Class: DEG_APCC_DBOX_1

Location: 756:764

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9079

ASA_SCORE: 96.4889

COIL: 0.8026

CONS_SCORE: 0.3872

DSS_SCORE: 0.4469

HELIX: 0.1723

FCONS_SCORE: 0.9556

RIG_SCORE: 0.7308

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P758L	TCGA-CV-7568	HNSC	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	0.6471
p.P758L	DO14160	HNSC	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.6471
p.A768T	TCGA-DU-6392	LGG	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222
p.A768T	DO22237	LGG	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222
p.R759C	TCGA-MX-A5UJ	STAD	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	0.719
p.R759C	DO48547	STAD	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.719
p.R759C	SIDM01609	Endometrial Carcinoma	GDSC	GRPRLEKLS	DEG_APCC_DBOX_1	0.719
p.R759C	ACH-000972	Endometrial/Uterine Cancer	CCLE	GRPRLEKLS	DEG_APCC_DBOX_1	0.719
p.V755I	DO230334	COCA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.3056
p.L763R	DO229051	LICA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.8428
p.P758Q	DO232863	NACA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.5924
p.A767V	DO232761	PBCA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.25
p.P752S	SIDM01104	Melanoma	GDSC	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222
p.P752S	ACH-000640	Skin Cancer	CCLE	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222
p.P752S	SK-MEL-31	skin	COSMIC	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222

Drug responses associated with DOT1L mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.K1228N (No)	GDSC	SGC0946	5.3527
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.K1228N (No)	GDSC	EPZ004777	98.992
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.K1228N (No)	GDSC	EPZ5676	112.79
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.M713V (No)	GDSC	SGC0946	4.3072
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.M713V (No)	GDSC	EPZ004777	24.636
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.M713V (No)	GDSC	EPZ5676	42.206
SIDM00578	NB\|neuroblastoma	p.P389T (No)	GDSC	SGC0946	3.0821
SIDM00578	NB\|neuroblastoma	p.P389T (No)	GDSC	EPZ004777	96.153
SIDM00578	NB\|neuroblastoma	p.P389T (No)	GDSC	EPZ5676	999.65
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A897V (No)	GDSC	SGC0946	3.6926
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A897V (No)	GDSC	EPZ004777	38.966
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A897V (No)	GDSC	EPZ5676	69.401
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A1335T (No)	GDSC	SGC0946	3.6926
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A1335T (No)	GDSC	EPZ004777	38.966
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A1335T (No)	GDSC	EPZ5676	69.401
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Y738* (No)	GDSC	SGC0946	6.3829
SIDM00572	STAD\|stomach	p.A1672T (No)	GDSC	SGC0946	7.1461
SIDM00572	STAD\|stomach	p.A1672T (No)	GDSC	EPZ004777	269.06
SIDM00572	STAD\|stomach	p.A1672T (No)	GDSC	EPZ5676	258.11
SIDM00122	BRCA\|breast	p.G1452_A1458delGGAASSA (No)	GDSC	SGC0946	11.0142
SIDM00122	BRCA\|breast	p.G1452_A1458delGGAASSA (No)	GDSC	EPZ004777	397.25
SIDM00122	BRCA\|breast	p.G1452_A1458delGGAASSA (No)	GDSC	EPZ5676	710.86
SIDM00544	NB\|neuroblastoma	p.T1403S (No)	GDSC	SGC0946	7.5045
SIDM00544	NB\|neuroblastoma	p.T1403S (No)	GDSC	EPZ004777	119.48
SIDM00544	NB\|neuroblastoma	p.T1403S (No)	GDSC	EPZ5676	263.91
SIDM01045	UCEC\|endometrium	p.V1165fs*28 (No)	GDSC	SGC0946	10.9662
SIDM01045	UCEC\|endometrium	p.V1165fs*28 (No)	GDSC	EPZ004777	386.01
SIDM01045	UCEC\|endometrium	p.V1165fs*28 (No)	GDSC	EPZ5676	681.4
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.V441M (No)	GDSC	SGC0946	2.8057
SIDM00901	UCEC\|endometrium	p.P474L (No)	GDSC	SGC0946	6.6406
SIDM00901	UCEC\|endometrium	p.P474L (No)	GDSC	EPZ004777	220.11
SIDM00901	UCEC\|endometrium	p.P474L (No)	GDSC	EPZ5676	288.27
SIDM00713	MESO\|mesothelioma	p.L533P (No)	GDSC	EPZ004777	430.37
SIDM00713	MESO\|mesothelioma	p.L533P (No)	GDSC	EPZ5676	621.26
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.R411L (No)	GDSC	SGC0946	4.0767
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.R411L (No)	GDSC	EPZ004777	131.58
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.R411L (No)	GDSC	EPZ5676	112.49
SIDM00937	HNSC\|head_and_neck	p.L162W (No)	GDSC	SGC0946	4.9182
SIDM00937	HNSC\|head_and_neck	p.L162W (No)	GDSC	EPZ004777	191.24
SIDM00937	HNSC\|head_and_neck	p.L162W (No)	GDSC	EPZ5676	175.09
SIDM00859	DLBC\|B_cell_lymphoma	p.Q745P (Yes)	GDSC	SGC0946	1.9199
SIDM00859	DLBC\|B_cell_lymphoma	p.Q745P (Yes)	GDSC	EPZ004777	38.406
SIDM00859	DLBC\|B_cell_lymphoma	p.Q745P (Yes)	GDSC	EPZ5676	97.544
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G165C (No)	GDSC	SGC0946	3.1451
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G165C (No)	GDSC	EPZ004777	222
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G165C (No)	GDSC	EPZ5676	219.87
SIDM00461	LAML\|acute_myeloid_leukaemia	p.V1418F (No)	GDSC	SGC0946	4.0544
SIDM00461	LAML\|acute_myeloid_leukaemia	p.V1418F (No)	GDSC	EPZ004777	25.51
SIDM00461	LAML\|acute_myeloid_leukaemia	p.V1418F (No)	GDSC	EPZ5676	29.736
SIDM00250	ESCA\|oesophagus	p.W208C (No)	GDSC	SGC0946	4.7425
SIDM00250	ESCA\|oesophagus	p.W208C (No)	GDSC	EPZ004777	148.24
SIDM00250	ESCA\|oesophagus	p.W208C (No)	GDSC	EPZ5676	183.66
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.G1095R (No)	GDSC	SGC0946	8.1398
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R1011W (No)	GDSC	SGC0946	4.5268
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R1011W (No)	GDSC	EPZ004777	62.142
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R1011W (No)	GDSC	EPZ5676	279.17
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1335V (No)	GDSC	SGC0946	4.5268
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1335V (No)	GDSC	EPZ004777	62.142
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1335V (No)	GDSC	EPZ5676	279.17
SIDM01007	ALL\|lymphoblastic_leukemia	p.A376G (No)	GDSC	SGC0946	3.4123
SIDM01007	ALL\|lymphoblastic_leukemia	p.A376G (No)	GDSC	EPZ004777	80.385
SIDM01007	ALL\|lymphoblastic_leukemia	p.A376G (No)	GDSC	EPZ5676	40.965
SIDM01007	ALL\|lymphoblastic_leukemia	p.G926W (No)	GDSC	SGC0946	3.4123
SIDM01007	ALL\|lymphoblastic_leukemia	p.G926W (No)	GDSC	EPZ004777	80.385
SIDM01007	ALL\|lymphoblastic_leukemia	p.G926W (No)	GDSC	EPZ5676	40.965
SIDM01007	ALL\|lymphoblastic_leukemia	p.A935V (No)	GDSC	SGC0946	3.4123
SIDM01007	ALL\|lymphoblastic_leukemia	p.A935V (No)	GDSC	EPZ004777	80.385
SIDM01007	ALL\|lymphoblastic_leukemia	p.A935V (No)	GDSC	EPZ5676	40.965
SIDM00391	MM\|myeloma	p.H1694Q (No)	GDSC	SGC0946	5.2088
SIDM00391	MM\|myeloma	p.H1694Q (No)	GDSC	EPZ004777	179.74
SIDM00391	MM\|myeloma	p.H1694Q (No)	GDSC	EPZ5676	131.4
SIDM00814	ACC\|adrenal_gland	p.T751P (Yes)	GDSC	SGC0946	5.669
SIDM00814	ACC\|adrenal_gland	p.T751P (Yes)	GDSC	EPZ004777	102.05
SIDM00814	ACC\|adrenal_gland	p.T751P (Yes)	GDSC	EPZ5676	160.49
SIDM00214	COREAD\|large_intestine	p.T751P (Yes)	GDSC	SGC0946	7.9059
SIDM00214	COREAD\|large_intestine	p.T751P (Yes)	GDSC	EPZ004777	344.69
SIDM00214	COREAD\|large_intestine	p.T751P (Yes)	GDSC	EPZ5676	366.91
SIDM01088	UNCLASSIFIED\|endometrium	p.R1091* (No)	GDSC	SGC0946	5.6364
SIDM01088	UNCLASSIFIED\|endometrium	p.R1091* (No)	GDSC	EPZ004777	142.05
SIDM01088	UNCLASSIFIED\|endometrium	p.R1091* (No)	GDSC	EPZ5676	266.99
SIDM01090	COREAD\|large_intestine	p.E47V (No)	GDSC	SGC0946	4.4107
SIDM01090	COREAD\|large_intestine	p.E47V (No)	GDSC	EPZ004777	71.182
SIDM01090	COREAD\|large_intestine	p.E47V (No)	GDSC	EPZ5676	67.344
SIDM01090	COREAD\|large_intestine	p.I48F (No)	GDSC	SGC0946	4.4107
SIDM01090	COREAD\|large_intestine	p.I48F (No)	GDSC	EPZ004777	71.182
SIDM01090	COREAD\|large_intestine	p.I48F (No)	GDSC	EPZ5676	67.344
SIDM00945	COREAD\|large_intestine	p.T751P (Yes)	GDSC	SGC0946	9.9651
SIDM00945	COREAD\|large_intestine	p.T751P (Yes)	GDSC	EPZ004777	393.67
SIDM00945	COREAD\|large_intestine	p.T751P (Yes)	GDSC	EPZ5676	396.31
SIDM00498	COREAD\|large_intestine	p.P298S (No)	GDSC	SGC0946	7.2553
SIDM00498	COREAD\|large_intestine	p.P298S (No)	GDSC	EPZ004777	270.94
SIDM00498	COREAD\|large_intestine	p.P298S (No)	GDSC	EPZ5676	328.54
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.G1725V (No)	GDSC	SGC0946	2.6114
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.G1725V (No)	GDSC	EPZ004777	23.75
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.G1725V (No)	GDSC	EPZ5676	55.568
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P709Q (No)	GDSC	SGC0946	11.8591
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P709Q (No)	GDSC	EPZ004777	236.43
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P709Q (No)	GDSC	EPZ5676	651.98
SIDM00946	ALL\|T_cell_leukemia	p.E1343K (No)	GDSC	SGC0946	3.5709
SIDM00946	ALL\|T_cell_leukemia	p.E1343K (No)	GDSC	EPZ004777	93.458
SIDM00946	ALL\|T_cell_leukemia	p.E1343K (No)	GDSC	EPZ5676	85.957
SIDM00946	ALL\|T_cell_leukemia	p.G1708V (No)	GDSC	SGC0946	3.5709
SIDM00946	ALL\|T_cell_leukemia	p.G1708V (No)	GDSC	EPZ004777	93.458
SIDM00946	ALL\|T_cell_leukemia	p.G1708V (No)	GDSC	EPZ5676	85.957
SIDM00404	DLBC\|B_cell_lymphoma	p.L162W (No)	GDSC	SGC0946	1.8645
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.S1083R (No)	GDSC	SGC0946	4.1294
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.S1083R (No)	GDSC	EPZ004777	44.06
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.S1083R (No)	GDSC	EPZ5676	140.38
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P479T (No)	GDSC	SGC0946	2.6303
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P479T (No)	GDSC	EPZ004777	146.64
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P479T (No)	GDSC	EPZ5676	245.74
SIDM00687	STAD\|stomach	p.S1152N (No)	GDSC	SGC0946	4.4003
SIDM00687	STAD\|stomach	p.S1152N (No)	GDSC	EPZ004777	990.67
SIDM00687	STAD\|stomach	p.S1152N (No)	GDSC	EPZ5676	1221
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.T751P (Yes)	GDSC	SGC0946	6.9692
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.T751P (Yes)	GDSC	EPZ004777	369.84
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.T751P (Yes)	GDSC	EPZ5676	840.31
SIDM00217	COREAD\|large_intestine	p.T1184A (No)	GDSC	SGC0946	5.1131
SIDM00217	COREAD\|large_intestine	p.T1184A (No)	GDSC	EPZ004777	325.37
SIDM00217	COREAD\|large_intestine	p.T1184A (No)	GDSC	EPZ5676	341.51
SIDM00217	COREAD\|large_intestine	p.A1454V (No)	GDSC	SGC0946	5.1131
SIDM00217	COREAD\|large_intestine	p.A1454V (No)	GDSC	EPZ004777	325.37
SIDM00217	COREAD\|large_intestine	p.A1454V (No)	GDSC	EPZ5676	341.51
SIDM00893	BRCA\|breast	p.K333E (No)	GDSC	SGC0946	6.5509
SIDM00893	BRCA\|breast	p.K333E (No)	GDSC	EPZ004777	63.962
SIDM00893	BRCA\|breast	p.K333E (No)	GDSC	EPZ5676	187.02
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A528V (No)	GDSC	SGC0946	5.6446
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A528V (No)	GDSC	EPZ004777	104.93
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A528V (No)	GDSC	EPZ5676	166.24
SIDM00849	KIRC\|kidney	p.K521delK (No)	GDSC	SGC0946	5.1634
SIDM00849	KIRC\|kidney	p.K521delK (No)	GDSC	EPZ004777	138.43
SIDM00849	KIRC\|kidney	p.K521delK (No)	GDSC	EPZ5676	140.6
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.A777D (No)	GDSC	SGC0946	1.8002
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.A777D (No)	GDSC	EPZ004777	80.63
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.A777D (No)	GDSC	EPZ5676	76.729
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.R782K (No)	GDSC	SGC0946	1.8002
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.R782K (No)	GDSC	EPZ004777	80.63
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.R782K (No)	GDSC	EPZ5676	76.729
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.L1659S (No)	GDSC	SGC0946	6.3367
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.L1659S (No)	GDSC	EPZ004777	139.21
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.L1659S (No)	GDSC	EPZ5676	67.103
SIDM01042	BRCA\|breast	p.I1676M (No)	GDSC	SGC0946	4.0699
SIDM01042	BRCA\|breast	p.I1676M (No)	GDSC	EPZ004777	71.477
SIDM01042	BRCA\|breast	p.I1676M (No)	GDSC	EPZ5676	121.87
SIDM00216	COREAD\|large_intestine	p.T1051A (No)	GDSC	EPZ004777	180.75
SIDM00216	COREAD\|large_intestine	p.T1051A (No)	GDSC	EPZ5676	224.46
SIDM00216	COREAD\|large_intestine	p.R1276Q (No)	GDSC	EPZ004777	180.75
SIDM00216	COREAD\|large_intestine	p.R1276Q (No)	GDSC	EPZ5676	224.46
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.K1255N (No)	GDSC	SGC0946	3.7715
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.K1255N (No)	GDSC	EPZ004777	44.575
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.K1255N (No)	GDSC	EPZ5676	46.251
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1454T (No)	GDSC	SGC0946	2.2136
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1454T (No)	GDSC	EPZ004777	220.95
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1454T (No)	GDSC	EPZ5676	163.13
SIDM00596	UCEC\|endometrium	p.T306M (No)	GDSC	SGC0946	2.85
SIDM00596	UCEC\|endometrium	p.T306M (No)	GDSC	EPZ004777	218.32
SIDM00596	UCEC\|endometrium	p.T306M (No)	GDSC	EPZ5676	506.05
SIDM00282	COREAD\|large_intestine	p.F243L (No)	GDSC	SGC0946	12.4667
SIDM00282	COREAD\|large_intestine	p.F243L (No)	GDSC	EPZ004777	238.02
SIDM00282	COREAD\|large_intestine	p.F243L (No)	GDSC	EPZ5676	153.31
SIDM00282	COREAD\|large_intestine	p.T984M (No)	GDSC	SGC0946	12.4667
SIDM00282	COREAD\|large_intestine	p.T984M (No)	GDSC	EPZ004777	238.02
SIDM00282	COREAD\|large_intestine	p.T984M (No)	GDSC	EPZ5676	153.31
SIDM00150	COREAD\|large_intestine	p.T1317I (No)	GDSC	SGC0946	0.2368
SIDM00150	COREAD\|large_intestine	p.T1317I (No)	GDSC	EPZ004777	166.89
SIDM00150	COREAD\|large_intestine	p.T1317I (No)	GDSC	EPZ5676	224.8
SIDM01100	NB\|neuroblastoma	p.K1255N (No)	GDSC	SGC0946	8.1768
SIDM01100	NB\|neuroblastoma	p.K1255N (No)	GDSC	EPZ004777	119.48
SIDM01100	NB\|neuroblastoma	p.K1255N (No)	GDSC	EPZ5676	196.03
SIDM00321	UNCLASSIFIED\|ovary	p.F1318C (No)	GDSC	SGC0946	5.8783
SIDM00321	UNCLASSIFIED\|ovary	p.F1318C (No)	GDSC	EPZ004777	250.33
SIDM00321	UNCLASSIFIED\|ovary	p.F1318C (No)	GDSC	EPZ5676	444.6
SIDM00630	BRCA\|breast	p.M96fs*1 (No)	GDSC	SGC0946	1.448
SIDM00630	BRCA\|breast	p.M96fs*1 (No)	GDSC	EPZ004777	75.05
SIDM00630	BRCA\|breast	p.M96fs*1 (No)	GDSC	EPZ5676	184.95
SIDM00363	LAML\|acute_myeloid_leukaemia	p.V1165fs*28 (No)	GDSC	SGC0946	3.0567
SIDM00363	LAML\|acute_myeloid_leukaemia	p.V1165fs*28 (No)	GDSC	EPZ004777	146.37
SIDM00363	LAML\|acute_myeloid_leukaemia	p.V1165fs*28 (No)	GDSC	EPZ5676	146.37
SIDM01050	UNCLASSIFIED\|biliary_tract	p.L1681P (No)	GDSC	SGC0946	9.5542
SIDM01050	UNCLASSIFIED\|biliary_tract	p.L1681P (No)	GDSC	EPZ004777	777.58
SIDM01050	UNCLASSIFIED\|biliary_tract	p.L1681P (No)	GDSC	EPZ5676	1909.1
SIDM00118	COREAD\|large_intestine	p.S1457fs*49 (No)	GDSC	SGC0946	0.4718
SIDM00118	COREAD\|large_intestine	p.S1457fs*49 (No)	GDSC	EPZ004777	94.939
SIDM00118	COREAD\|large_intestine	p.S1457fs*49 (No)	GDSC	EPZ5676	106.67
SIDM00660	COREAD\|large_intestine	p.V1165fs*8 (No)	GDSC	SGC0946	8.0199
SIDM00660	COREAD\|large_intestine	p.V1165fs*8 (No)	GDSC	EPZ004777	478.14
SIDM00660	COREAD\|large_intestine	p.V1165fs*8 (No)	GDSC	EPZ5676	452.51
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.I1204fs*6 (No)	GDSC	SGC0946	4.8173
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.I1204fs*6 (No)	GDSC	EPZ004777	309.2
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.I1204fs*6 (No)	GDSC	EPZ5676	311.23
SIDM00819	KIRC\|kidney	p.G594S (No)	GDSC	SGC0946	6.8098
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1059L (No)	GDSC	SGC0946	14.6332
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1059L (No)	GDSC	EPZ004777	1109.5
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1059L (No)	GDSC	EPZ5676	1588.3
SIDM00487	COREAD\|large_intestine	p.T100M (No)	GDSC	SGC0946	8.1265
SIDM00487	COREAD\|large_intestine	p.T100M (No)	GDSC	EPZ004777	76.672
SIDM00487	COREAD\|large_intestine	p.T100M (No)	GDSC	EPZ5676	275.05
SIDM00582	PAAD\|pancreas	p.Y58* (No)	GDSC	SGC0946	6.9363
SIDM00582	PAAD\|pancreas	p.Y58* (No)	GDSC	EPZ004777	322.02
SIDM00582	PAAD\|pancreas	p.Y58* (No)	GDSC	EPZ5676	291.92
SIDM00092	OV\|ovary	p.G1536R (No)	GDSC	SGC0946	11.0082
SIDM00092	OV\|ovary	p.G1536R (No)	GDSC	EPZ004777	439.82
SIDM00092	OV\|ovary	p.G1536R (No)	GDSC	EPZ5676	457.14
SIDM00545	SKCM\|melanoma	p.S132F (No)	GDSC	SGC0946	10.0095
SIDM00545	SKCM\|melanoma	p.S132F (No)	GDSC	EPZ004777	307.23
SIDM00545	SKCM\|melanoma	p.S132F (No)	GDSC	EPZ5676	359.48
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.T751P (Yes)	GDSC	SGC0946	4.3976
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.T751P (Yes)	GDSC	EPZ004777	48.554
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.T751P (Yes)	GDSC	EPZ5676	46.97
SIDM00930	UNCLASSIFIED\|osteosarcoma	p.S1299T (No)	GDSC	SGC0946	11.7202
SIDM00930	UNCLASSIFIED\|osteosarcoma	p.S1299T (No)	GDSC	EPZ004777	62.546
SIDM00930	UNCLASSIFIED\|osteosarcoma	p.S1299T (No)	GDSC	EPZ5676	351.77
SIDM00992	THCA\|thyroid	p.S1407R (No)	GDSC	SGC0946	4.011
SIDM00992	THCA\|thyroid	p.S1407R (No)	GDSC	EPZ004777	221.13
SIDM00992	THCA\|thyroid	p.S1407R (No)	GDSC	EPZ5676	585.83
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I85T (No)	GDSC	SGC0946	4.4346
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I85T (No)	GDSC	EPZ004777	195.58
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I85T (No)	GDSC	EPZ5676	108.81
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A1000T (No)	GDSC	SGC0946	4.4346
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A1000T (No)	GDSC	EPZ004777	195.58
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A1000T (No)	GDSC	EPZ5676	108.81
SIDM00986	HNSC\|head_and_neck	p.S1663C (No)	GDSC	SGC0946	5.0469
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.T93M (No)	GDSC	SGC0946	4.8173
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.T93M (No)	GDSC	EPZ004777	309.2
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.T93M (No)	GDSC	EPZ5676	311.23
SIDM00286	NB\|neuroblastoma	p.T751P (Yes)	GDSC	SGC0946	3.0131
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1662fs*>79 (No)	GDSC	SGC0946	3.9289
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1662fs*>79 (No)	GDSC	EPZ004777	39.964
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1662fs*>79 (No)	GDSC	EPZ5676	122.19
SIDM00606	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A717S (No)	GDSC	SGC0946	10.9469
SIDM00606	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A717S (No)	GDSC	EPZ004777	126.14
SIDM00606	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A717S (No)	GDSC	EPZ5676	348.15
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.R231L (No)	GDSC	SGC0946	5.5203
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.R231L (No)	GDSC	EPZ004777	428.81
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.R231L (No)	GDSC	EPZ5676	525.77
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.T790M (No)	GDSC	SGC0946	2.5328
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.T790M (No)	GDSC	EPZ004777	52.718
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.T790M (No)	GDSC	EPZ5676	84.097
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.A1686P (No)	GDSC	SGC0946	3.0397
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.A1686P (No)	GDSC	EPZ004777	69.047
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.A1686P (No)	GDSC	EPZ5676	28.529
SIDM00837	COREAD\|large_intestine	p.S1083I (No)	GDSC	SGC0946	5.7676
SIDM00837	COREAD\|large_intestine	p.S1083I (No)	GDSC	EPZ004777	130.68
SIDM00837	COREAD\|large_intestine	p.S1083I (No)	GDSC	EPZ5676	553.54
SIDM01104	SKCM\|melanoma	p.P752S (Yes)	GDSC	SGC0946	11.6661
SIDM00278	ESCA\|oesophagus	p.A687V (No)	GDSC	SGC0946	6.0131
SIDM00278	ESCA\|oesophagus	p.A687V (No)	GDSC	EPZ004777	132.98
SIDM00278	ESCA\|oesophagus	p.A687V (No)	GDSC	EPZ5676	116.92
SIDM00123	KIRC\|kidney	p.S997L (No)	GDSC	SGC0946	7.2768
SIDM00123	KIRC\|kidney	p.S997L (No)	GDSC	EPZ004777	260.47
SIDM00123	KIRC\|kidney	p.S997L (No)	GDSC	EPZ5676	550.65
SIDM00193	COREAD\|large_intestine	p.A483T (No)	GDSC	SGC0946	11.0235
SIDM00193	COREAD\|large_intestine	p.A483T (No)	GDSC	EPZ004777	124.2
SIDM00193	COREAD\|large_intestine	p.A483T (No)	GDSC	EPZ5676	122.08
SIDM00118	COREAD\|large_intestine	p.K1203N (No)	GDSC	SGC0946	0.4718
SIDM00118	COREAD\|large_intestine	p.K1203N (No)	GDSC	EPZ004777	94.939
SIDM00118	COREAD\|large_intestine	p.K1203N (No)	GDSC	EPZ5676	106.67

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRPRLEKLS

Degron related mutations and impact score

Drug responses associated with DOT1L mutations

All proteins holding degron of GRPRLEKLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	DEG_APCC_DBOX_1	756:764	GRPRLEKLS	APC,CDC20,FZR1	0.9079	More...