DegronMD

Uniprot ID: Q8TEK3

Source protein: Histone-lysine N-methyltransferase, H3 lysine-79 specific

Source gene: DOT1L

Class: DEG_APCC_DBOX_1

Location: 756:764

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9079

ASA_SCORE: 96.4889

COIL: 0.8026

CONS_SCORE: 0.3872

DSS_SCORE: 0.4469

HELIX: 0.1723

FCONS_SCORE: 0.9556

RIG_SCORE: 0.7308

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L763R	DO229051	LICA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.8428
p.R759C	TCGA-MX-A5UJ	STAD	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	0.719
p.R759C	DO48547	STAD	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.719
p.R759C	SIDM01609	Endometrial Carcinoma	GDSC	GRPRLEKLS	DEG_APCC_DBOX_1	0.719
p.R759C	ACH-000972	Endometrial/Uterine Cancer	CCLE	GRPRLEKLS	DEG_APCC_DBOX_1	0.719
p.P758L	TCGA-CV-7568	HNSC	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	0.6471
p.P758L	DO14160	HNSC	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.6471
p.P758Q	DO232863	NACA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.5924
p.V755I	DO230334	COCA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.3056
p.A767V	DO232761	PBCA	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.25
p.A768T	TCGA-DU-6392	LGG	TCGA	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222
p.A768T	DO22237	LGG	ICGC	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222
p.P752S	SIDM01104	Melanoma	GDSC	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222
p.P752S	ACH-000640	Skin Cancer	CCLE	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222
p.P752S	SK-MEL-31	skin	COSMIC	GRPRLEKLS	DEG_APCC_DBOX_1	0.2222

Showing 1 to 15 of 15 entries

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Drug responses associated with DOT1L mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00814	ACC\|adrenal_gland	p.T751P (Yes)	GDSC	SGC0946	5.669
SIDM00814	ACC\|adrenal_gland	p.T751P (Yes)	GDSC	EPZ004777	102.05
SIDM00814	ACC\|adrenal_gland	p.T751P (Yes)	GDSC	EPZ5676	160.49
SIDM01007	ALL\|lymphoblastic_leukemia	p.A376G (No)	GDSC	SGC0946	3.4123
SIDM01007	ALL\|lymphoblastic_leukemia	p.A376G (No)	GDSC	EPZ004777	80.385
SIDM01007	ALL\|lymphoblastic_leukemia	p.A376G (No)	GDSC	EPZ5676	40.965
SIDM01007	ALL\|lymphoblastic_leukemia	p.G926W (No)	GDSC	SGC0946	3.4123
SIDM01007	ALL\|lymphoblastic_leukemia	p.G926W (No)	GDSC	EPZ004777	80.385
SIDM01007	ALL\|lymphoblastic_leukemia	p.G926W (No)	GDSC	EPZ5676	40.965
SIDM01007	ALL\|lymphoblastic_leukemia	p.A935V (No)	GDSC	SGC0946	3.4123
SIDM01007	ALL\|lymphoblastic_leukemia	p.A935V (No)	GDSC	EPZ004777	80.385
SIDM01007	ALL\|lymphoblastic_leukemia	p.A935V (No)	GDSC	EPZ5676	40.965
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.G1725V (No)	GDSC	SGC0946	2.6114
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.G1725V (No)	GDSC	EPZ004777	23.75
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.G1725V (No)	GDSC	EPZ5676	55.568
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.A777D (No)	GDSC	SGC0946	1.8002
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.A777D (No)	GDSC	EPZ004777	80.63
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.A777D (No)	GDSC	EPZ5676	76.729
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.R782K (No)	GDSC	SGC0946	1.8002
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.R782K (No)	GDSC	EPZ004777	80.63
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.R782K (No)	GDSC	EPZ5676	76.729
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I85T (No)	GDSC	SGC0946	4.4346
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I85T (No)	GDSC	EPZ004777	195.58
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I85T (No)	GDSC	EPZ5676	108.81
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A1000T (No)	GDSC	SGC0946	4.4346

Showing 1 to 25 of 257 entries

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All proteins holding degron of GRPRLEKLS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	DEG_APCC_DBOX_1	756:764	GRPRLEKLS	APC,CDC20,FZR1	0.9079	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRPRLEKLS

Degron related mutations and impact score

Drug responses associated with DOT1L mutations

All proteins holding degron of GRPRLEKLS