DegronMD

Uniprot ID: Q08AE8

Source protein: Protein spire homolog 1

Source gene: SPIRE1

Class: DEG_APCC_DBOX_1

Location: 347:355

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9616

ASA_SCORE: 90.8778

COIL: 0.8859

CONS_SCORE: 0.6311

DSS_SCORE: 0.4348

HELIX: 0.0912

FCONS_SCORE: 1.1572

RIG_SCORE: 0.6604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P353Q	TCGA-09-2044	OV	TCGA	SRPPLNPVS	DEG_APCC_DBOX_1	0.5924
p.P353Q	DO28923	OV	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	0.5924
p.R365Q	TCGA-AR-A250	BRCA	TCGA	SRPPLNPVS	DEG_APCC_DBOX_1	0.0556
p.R365Q	DO1802	BRCA	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	0.0556
p.P353S	TCGA-BS-A0UV	UCEC	TCGA	SRPPLNPVS	DEG_APCC_DBOX_1	0.5641
p.P353S	DO42793	UCEC	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	0.5641
p.P361T	DO228948	LICA	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	0.1667
p.T362N	DO229036	LICA	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	0.5833
p.K360I	DO23524	LIRI	ICGC	SRPPLNPVS	DEG_APCC_DBOX_1	0.3056
p.P350L	SIDM00086	Kidney Carcinoma	GDSC	SRPPLNPVS	DEG_APCC_DBOX_1	0.6471
p.P350L	ACH-002195	Kidney Cancer	CCLE	SRPPLNPVS	DEG_APCC_DBOX_1	0.6471
p.P350L	RXF393	kidney	COSMIC	SRPPLNPVS	DEG_APCC_DBOX_1	0.6471
p.E343K	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	SRPPLNPVS	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08AE8	Protein spire homolog 1	DEG_APCC_DBOX_1	347:355	SRPPLNPVS	APC,CDC20,FZR1	0.9616	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons