DegronMD

Uniprot ID: Q7LBC6

Source protein: Lysine-specific demethylase 3B

Source gene: KDM3B

Class: DEG_SPOP_SBC_1

Location: 1318:1322

E3 ligase: SPOP

DEGRON score: 0.9967

ASA_SCORE: 75.82

COIL: 0.812

CONS_SCORE: 0.4684

DSS_SCORE: 0.3799

HELIX: 0.066

FCONS_SCORE: 0.9479

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1324P	TCGA-CK-4951	COAD	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2778
p.K1327N	TCGA-D8-A1JA	BRCA	TCGA	VFSTS	DEG_SPOP_SBC_1	0.6389
p.S1322F	TCGA-DA-A960	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	0.7982
p.P1314L	TCGA-EE-A3AG	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2222
p.R1315H	DO5242	BRCA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.25
p.R1315H	DO44442	HNSC	ICGC	VFSTS	DEG_SPOP_SBC_1	0.25
p.Y1319C	DO20841	KIRP	ICGC	VFSTS	DEG_SPOP_SBC_1	0.7087
p.Q1331H	DO44832	LICA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.5278
p.R1315C	DO222557	MELA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.25
p.G1323V	DO37742	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	0.3056
p.T1321A	SIDM00455	Pancreatic Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.7139
p.T1321A	ACH-000599	Pancreatic Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.7139
p.T1321A	PA-TU-8902	pancreas	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.7139
p.P1316L	SIDM00458	Acute Myeloid Leukemia	GDSC	VFSTS	DEG_SPOP_SBC_1	0.2778
p.P1316L	ACH-000751	Leukemia	CCLE	VFSTS	DEG_SPOP_SBC_1	0.2778
p.P1316L	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31274	Homeobox protein Hox-C9	DEG_SPOP_SBC_1	61:65	VFSTS	SPOP	0.5518	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SPOP_SBC_1	411:415	VFSTS	SPOP	0.5201	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1028:1032	VFSTS	SPOP	0.9188	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_SPOP_SBC_1	1318:1322	VFSTS	SPOP	0.9967	More...
Q99594	Transcriptional enhancer factor TEF-5	DEG_SPOP_SBC_1	154:158	VFSTS	SPOP	0.9993	More...
Q9UMZ2	Synergin gamma	DEG_SPOP_SBC_1	636:640	VFSTS	SPOP	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons