DegronMD

Uniprot ID: Q99594

Source protein: Transcriptional enhancer factor TEF-5

Source gene: TEAD3

Class: DEG_SPOP_SBC_1

Location: 154:158

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 42.98

COIL: 0.8046

CONS_SCORE: 0.3408

DSS_SCORE: 0.4484

HELIX: 0.0952

FCONS_SCORE: 1.314

RIG_SCORE: 0.7055

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S156F	TCGA-EE-A2MJ	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	0.7982
p.S156F	DO38099	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	0.7982
p.S158F	TCGA-WE-A8ZX	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	0.7982
p.S158F	DO51291	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	0.7982
p.R158S	ACH-001049	Lung Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.7427
p.R158S	CPC-N	lung	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.7427
p.D157E	ACH-001049	Lung Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	0.6758
p.D157E	CPC-N	lung	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.6758
p.V154A	ACH-002272	Lymphoma	CCLE	VFSTS	DEG_SPOP_SBC_1	0.5825
p.V154A	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.5825
p.R160W	TCGA-A6-6654	COAD	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2778
p.R160W	DO9498	COAD	ICGC	VFSTS	DEG_SPOP_SBC_1	0.2778
p.R160W	SIDM00596	Endometrial Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	0.2778
p.R160W	HEC-1	endometrium	COSMIC	VFSTS	DEG_SPOP_SBC_1	0.2778
p.R160Q	TCGA-DH-5144	LGG	TCGA	VFSTS	DEG_SPOP_SBC_1	0.2778
p.R160Q	DO22175	LGG	ICGC	VFSTS	DEG_SPOP_SBC_1	0.2778
p.L168V	TCGA-B6-A0RS	BRCA	TCGA	VFSTS	DEG_SPOP_SBC_1	0.0556
p.L168V	DO4012	BRCA	ICGC	VFSTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31274	Homeobox protein Hox-C9	DEG_SPOP_SBC_1	61:65	VFSTS	SPOP	0.5518	More...
Q7LBC6	Lysine-specific demethylase 3B	DEG_SPOP_SBC_1	1318:1322	VFSTS	SPOP	0.9967	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1028:1032	VFSTS	SPOP	0.9188	More...
Q9UMZ2	Synergin gamma	DEG_SPOP_SBC_1	636:640	VFSTS	SPOP	0.9936	More...
Q99594	Transcriptional enhancer factor TEF-5	DEG_SPOP_SBC_1	154:158	VFSTS	SPOP	0.9993	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SPOP_SBC_1	411:415	VFSTS	SPOP	0.5201	More...

Showing 1 to 6 of 6 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons