DegronMD - Q5JUK3(KCNT1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1024H	TCGA-12-5299	GBM	TCGA	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.2222
p.R1200S	TCGA-78-7146	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2778
p.Q1212H	TCGA-AC-A23H	BRCA	TCGA	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1667
p.V1207M	TCGA-B1-5398	KIRP	TCGA	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.3056
p.P1192S	TCGA-BG-A222	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.0556
p.P1192S	SIDM00659	Glioblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.0556
p.P1192S	ACH-001118	Brain Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.0556
p.P1192S	M059J	central nervous system	COSMIC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.0556
p.R1020H	TCGA-DC-6160	READ	TCGA	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1111
p.R1020H	SIDM00217	Colorectal Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1111
p.R1020H	SNU-1040	large intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1111
p.G1039D	TCGA-E2-A155	BRCA	TCGA	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1389
p.D1194G	TCGA-FI-A2D5	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1111
p.D1033N	DO51925	BLCA	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.3056
p.E1023K	DO219041	BLCA	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1944
p.G1018D	DO1707	BRCA	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.0556
p.Q1211H	DO2401	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1944
p.R1199C	DO233282	GACA	ICGC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.25
p.V1206M	DO20930	KIRP	ICGC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation altering degron motif	0.7208
p.R1199L	DO229032	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.25
p.P1031R	DO23504	LINC	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7512
p.R1199S	DO23717	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.25
p.S1028F	DO37941	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7982
p.P1031L	DO42033	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7582
p.D1193G	DO41331	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.0833
p.R1214Q	SIDM00960	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1111
p.R1214Q	SIDM00712	Non-Cancerous	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1111
p.R1214Q	SIDM00713	Mesothelioma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1111
p.R1214Q	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1111
p.R1214Q	SIDM00622	Glioblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1111
p.R1214Q	SIDM00083	Glioblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1111
p.R1024C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.2222
p.R1024C	ACH-002059	Leukemia	CCLE	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.2222
p.R1024C	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.2222
p.S1032F	SIDM00414	Bladder Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7982
p.S1032F	ACH-000545	Bladder Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7982
p.S1032F	VM-CUB-1	urinary tract	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7982
p.R1200H	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2778
p.R1200H	ACH-002311	Esophageal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2778
p.R1200H	TE-12	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2778
p.R1020S	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1111
p.R1020S	ACH-000416	Lung Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1111
p.R1020S	NCI-H838	lung	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1111
p.L1198F	SIDM01343	Gastric Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2222
p.L1198F	ACH-000490	Cervical Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2222
p.L1198F	ACH-000764	Gastric Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2222
p.V1027M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.3056
p.S1018L	HUTU-80	small intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.0556
p.R1195H	TE-12	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1389
p.E1031K	SNU-1040	large intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7022
p.V1033M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.3056
p.S1030L	HUTU-80	small intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7667
p.S1032L	HUTU-80	small intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7667
p.P1213S	M059J	central nervous system	COSMIC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1389
p.E1033K	SNU-1040	large intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.3056
p.V1021M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1389
p.V1040M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.1111
p.E1019K	SNU-1040	large intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.0833
p.P1194S	M059J	central nervous system	COSMIC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.1111
p.R1202H	TE-12	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNT1

UniProt ID: Q5JUK3

Entrez ID: 57582

Protein name: Potassium channel subfamily T member 1 (KCa4.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNT1 in