DegronMD - Q5JUK3(KCNT1)

FUNCTION: Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). {ECO:0000250}.

GO - Biological processes (BP):

GO - Molecular function (MF): intracellular sodium activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271]

GO - Cellular component (CC): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1202H	TE-12	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation altering degron motif	0.8244
p.S1028F	DO37941	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7982
p.S1032F	SIDM00414	Bladder Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7982
p.S1032F	ACH-000545	Bladder Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7982
p.S1032F	VM-CUB-1	urinary tract	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7982
p.S1030L	HUTU-80	small intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7667
p.S1032L	HUTU-80	small intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7667
p.P1031L	DO42033	UCEC	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7582
p.P1031R	DO23504	LINC	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7512
p.V1206M	DO20930	KIRP	ICGC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation altering degron motif	0.7208
p.E1031K	SNU-1040	large intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation altering degron motif	0.7022
p.V1207M	TCGA-B1-5398	KIRP	TCGA	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.3056
p.D1033N	DO51925	BLCA	ICGC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.3056
p.V1027M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.3056
p.V1033M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.3056
p.E1033K	SNU-1040	large intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	1028:1032	Mutation rewiring degron network	0.3056
p.R1200S	TCGA-78-7146	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2778
p.R1200H	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2778
p.R1200H	ACH-002311	Esophageal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2778
p.R1200H	TE-12	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	1202:1206	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 60 entries

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Kaplan plot for KCNT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNT1

UniProt ID: Q5JUK3

Entrez ID: 57582

Protein name: Potassium channel subfamily T member 1 (KCa4.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNT1 in