DegronMD

Uniprot ID: Q5JUK3

Source protein: Potassium channel subfamily T member 1

Source gene: KCNT1

Class: DEG_SPOP_SBC_1

Location: 1202:1206

E3 ligase: SPOP

DEGRON score: 0.9307

ASA_SCORE: 70.68

COIL: 0.865

CONS_SCORE: 0.2787

DSS_SCORE: 0.47

HELIX: 0.0996

FCONS_SCORE: 0.8612

RIG_SCORE: 0.6377

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1202H	TE-12	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	0.8244
p.V1206M	DO20930	KIRP	ICGC	VASSS	DEG_SPOP_SBC_1	0.7208
p.V1207M	TCGA-B1-5398	KIRP	TCGA	VASSS	DEG_SPOP_SBC_1	0.3056
p.R1200S	TCGA-78-7146	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	0.2778
p.R1200H	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.2778
p.R1200H	ACH-002311	Esophageal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.2778
p.R1200H	TE-12	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	0.2778
p.R1199C	DO233282	GACA	ICGC	VASSS	DEG_SPOP_SBC_1	0.25
p.R1199L	DO229032	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	0.25
p.R1199S	DO23717	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.25
p.L1198F	SIDM01343	Gastric Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.2222
p.L1198F	ACH-000490	Cervical Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.2222
p.L1198F	ACH-000764	Gastric Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.2222
p.Q1211H	DO2401	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	0.1944
p.Q1212H	TCGA-AC-A23H	BRCA	TCGA	VASSS	DEG_SPOP_SBC_1	0.1667
p.R1195H	TE-12	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1389
p.P1213S	M059J	central_nervous_system	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1389
p.D1194G	TCGA-FI-A2D5	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	0.1111
p.R1214Q	SIDM00960	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.R1214Q	SIDM00712	Non-Cancerous	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.R1214Q	SIDM00713	Mesothelioma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.R1214Q	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.R1214Q	SIDM00622	Glioblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.R1214Q	SIDM00083	Glioblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.P1194S	M059J	central_nervous_system	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1111

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Drug responses associated with KCNT1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VASSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	931:935	VASSS	SPOP	0.6437	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2071:2075	VASSS	SPOP	0.8357	More...
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_SPOP_SBC_1	247:251	VASSS	SPOP	0.9642	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2973:2977	VASSS	SPOP	0.9629	More...
Q9BWW9	Apolipoprotein L5	DEG_SPOP_SBC_1	140:144	VASSS	SPOP	0.5682	More...
Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14	DEG_SPOP_SBC_1	196:200	VASSS	SPOP	0.6707	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	888:892	VASSS	SPOP	0.8649	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1037:1041	VASSS	SPOP	0.5544	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1391:1395	VASSS	SPOP	0.9996	More...
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_SPOP_SBC_1	387:391	VASSS	SPOP	0.9672	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1040:1044	VASSS	SPOP	0.9979	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	570:574	VASSS	SPOP	0.9829	More...
P57058	Hormonally up-regulated neu tumor-associated kinase	DEG_SPOP_SBC_1	513:517	VASSS	SPOP	0.9759	More...
Q96L93	Kinesin-like protein KIF16B	DEG_SPOP_SBC_1	1096:1100	VASSS	SPOP	0.9957	More...
Q86Y91	Kinesin-like protein KIF18B	DEG_SPOP_SBC_1	787:791	VASSS	SPOP	0.9955	More...
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	63:67	VASSS	SPOP	0.9895	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	187:191	VASSS	SPOP	0.9697	More...
Q9NRR6	Phosphatidylinositol polyphosphate 5-phosphatase type IV	DEG_SPOP_SBC_1	164:168	VASSS	SPOP	0.9986	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1202:1206	VASSS	SPOP	0.9307	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1052:1056	VASSS	SPOP	0.9974	More...
Q8IYM0	Protein FAM186B	DEG_SPOP_SBC_1	859:863	VASSS	SPOP	0.9006	More...
Q5T0W9	Protein FAM83B	DEG_SPOP_SBC_1	425:429	VASSS	SPOP	0.9994	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	230:234	VASSS	SPOP	0.9994	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1700:1704	VASSS	SPOP	0.9907	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_SPOP_SBC_1	327:331	VASSS	SPOP	0.9253	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASSS

Degron related mutations and impact score

Drug responses associated with KCNT1 mutations

All proteins holding degron of VASSS