DegronMD - Q9UGK3(STAP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P318L	TCGA-38-4632	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.P318L	DO23858	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.G317D	TCGA-AJ-A3BH	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.G317D	DO41638	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.G317D	SIDM00290	Gastric Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.G317D	ACH-000847	Gastric Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.G317D	HGC-27	stomach	COSMIC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.V269M	TCGA-D1-A103	UCEC	TCGA	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.1944
p.V269M	TCGA-D1-A103	UCEC	TCGA	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation rewiring degron network	0.2222
p.V269M	DO42312	UCEC	ICGC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.1944
p.V269M	DO42312	UCEC	ICGC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation rewiring degron network	0.2222
p.V269M	ACH-000999	Colon/Colorectal Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.1944
p.V269M	ACH-000999	Colon/Colorectal Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation rewiring degron network	0.2222
p.P333S	TCGA-DF-A2KU	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2778
p.P333S	DO223286	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2778
p.D260N	TCGA-E9-A6HE	BRCA	TCGA	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation altering degron motif	0.5821
p.D260N	TCGA-E9-A6HE	BRCA	TCGA	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation altering degron motif	0.5821
p.D260N	DO50048	BRCA	ICGC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation altering degron motif	0.5821
p.D260N	DO50048	BRCA	ICGC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation altering degron motif	0.5821
p.K252N	TCGA-EE-A29G	SKCM	TCGA	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation substituting flanking lysine	0.2222
p.K252N	TCGA-EE-A29G	SKCM	TCGA	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation substituting flanking lysine	0.2222
p.K252N	DO47303	SKCM	ICGC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation substituting flanking lysine	0.2222
p.K252N	DO47303	SKCM	ICGC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation substituting flanking lysine	0.2222
p.D326G	TCGA-OL-A66J	BRCA	TCGA	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.3056
p.D326G	DO44153	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.3056
p.A270V	DO222973	BTCA	ICGC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.1667
p.A270V	DO222973	BTCA	ICGC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation rewiring degron network	0.1944
p.G275S	DO228944	LICA	ICGC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation rewiring degron network	0.0556
p.P333Q	DO229029	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2778
p.Y256F	DO228349	MALY	ICGC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation blocking phosphorylation signal	0.6667
p.Y256F	DO228349	MALY	ICGC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation blocking phosphorylation signal	0.6667
p.Y256F	SIDM00641	Burkitt's Lymphoma	GDSC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation blocking phosphorylation signal	0.6667
p.Y256F	SIDM00641	Burkitt's Lymphoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation blocking phosphorylation signal	0.6667
p.V257M	SIDM01113	Other Sarcomas	GDSC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.25
p.V257M	SIDM01113	Other Sarcomas	GDSC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation rewiring degron network	0.25
p.P274A	SIDM00539	Esophageal Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.P274A	SIDM00539	Esophageal Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation rewiring degron network	0.0833
p.P274A	ACH-001496	Esophageal Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.P274A	ACH-001496	Esophageal Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation rewiring degron network	0.0833
p.D260Y	SIDM01061	Oral Cavity Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation altering degron motif	0.6214
p.D260Y	SIDM01061	Oral Cavity Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation altering degron motif	0.7325
p.P318Q	SIDM01187	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.P318Q	UACC-812	breast	COSMIC	VASSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.Y250N	ACH-001735	Leukemia	CCLE	DKENG	DEG_APCC_KENBOX_2	260:264	Mutation blocking phosphorylation signal	0.5
p.Y250N	ACH-001735	Leukemia	CCLE	DKENGE	DEG_Kelch_Keap1_1	260:265	Mutation blocking phosphorylation signal	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAP2

UniProt ID: Q9UGK3

Entrez ID: 55620

Protein name: Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for STAP2 in