DegronMD

Uniprot ID: Q9UGK3

Source protein: Signal-transducing adaptor protein 2

Source gene: STAP2

Class: DEG_Kelch_Keap1_1

Location: 260:265

E3 ligase: KEAP1

DEGRON score: 0.9527

ASA_SCORE: 92.0833

COIL: 0.6975

CONS_SCORE: 0.59

DSS_SCORE: 0.347

HELIX: 0.2482

FCONS_SCORE: 1.1682

RIG_SCORE: 0.7231

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V269M	TCGA-D1-A103	UCEC	TCGA	DKENGE	DEG_Kelch_Keap1_1	0.2222
p.V269M	DO42312	UCEC	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.2222
p.V269M	ACH-000999	Colon/Colorectal Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	0.2222
p.D260N	TCGA-E9-A6HE	BRCA	TCGA	DKENGE	DEG_Kelch_Keap1_1	0.5821
p.D260N	DO50048	BRCA	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.5821
p.K252N	TCGA-EE-A29G	SKCM	TCGA	DKENGE	DEG_Kelch_Keap1_1	0.2222
p.K252N	DO47303	SKCM	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.2222
p.A270V	DO222973	BTCA	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.1944
p.G275S	DO228944	LICA	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.0556
p.Y256F	DO228349	MALY	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.6667
p.Y256F	SIDM00641	Burkitt's Lymphoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	0.6667
p.V257M	SIDM01113	Other Sarcomas	GDSC	DKENGE	DEG_Kelch_Keap1_1	0.25
p.P274A	SIDM00539	Esophageal Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	0.0833
p.P274A	ACH-001496	Esophageal Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	0.0833
p.D260Y	SIDM01061	Oral Cavity Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	0.7325
p.Y250N	ACH-001735	Leukemia	CCLE	DKENGE	DEG_Kelch_Keap1_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95997	Securin	DEG_Kelch_Keap1_1	8:13	DKENGE	KEAP1	0.9951	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_Kelch_Keap1_1	588:593	DKENGE	KEAP1	0.9671	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_Kelch_Keap1_1	260:265	DKENGE	KEAP1	0.9527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons