DegronMD

Uniprot ID: O95997

Source protein: Securin

Source gene: PTTG1

Class: DEG_Kelch_Keap1_1

Location: 8:13

E3 ligase: KEAP1

DEGRON score: 0.9951

ASA_SCORE: 73.5333

COIL: 0.6823

CONS_SCORE: 0.803

DSS_SCORE: 0.4265

HELIX: 0.0892

FCONS_SCORE: 1.2342

RIG_SCORE: 0.7252

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I5S	SIDM01043	Other Sarcomas	GDSC	DKENGE	DEG_Kelch_Keap1_1	0.6944
p.I5S	ACH-000913	Endometrial/Uterine Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	0.6944
p.I5S	ESS-1	endometrium	COSMIC	DKENGE	DEG_Kelch_Keap1_1	0.6944
p.E10D	DO8264	COAD	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.5647
p.R17L	DO229031	LICA	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.2222
p.D22Y	DO228948	LICA	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.0833

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95997	Securin	DEG_Kelch_Keap1_1	8:13	DKENGE	KEAP1	0.9951	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_Kelch_Keap1_1	260:265	DKENGE	KEAP1	0.9527	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_Kelch_Keap1_1	588:593	DKENGE	KEAP1	0.9671	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons