DegronMD

Uniprot ID: Q6UVJ0

Source protein: Spindle assembly abnormal protein 6 homolog

Source gene: SASS6

Class: DEG_Kelch_Keap1_1

Location: 588:593

E3 ligase: KEAP1

DEGRON score: 0.9671

ASA_SCORE: 98.0333

COIL: 0.8385

CONS_SCORE: 0.3208

DSS_SCORE: 0.498

HELIX: 0.1353

FCONS_SCORE: 1.017

RIG_SCORE: 0.6722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G578A	TCGA-52-7810	LUSC	TCGA	DKENGE	DEG_Kelch_Keap1_1	0.0556
p.G578A	DO27381	LUSC	ICGC	DKENGE	DEG_Kelch_Keap1_1	0.0556
p.K589N	TCGA-MX-A5UJ	STAD	TCGA	DKENGE	DEG_Kelch_Keap1_1	0.5806
p.G578R	SIDM02077	Colorectal Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	0.0556
p.E593K	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	0.7022
p.E593K	ACH-000438	Lung Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	0.7022
p.E593K	LU-65	lung	COSMIC	DKENGE	DEG_Kelch_Keap1_1	0.7022
p.G596R	SIDM00905	Cervical Carcinoma	GDSC	DKENGE	DEG_Kelch_Keap1_1	0.25
p.G596R	ACH-001334	Cervical Cancer	CCLE	DKENGE	DEG_Kelch_Keap1_1	0.25
p.G596R	C-4-I	cervix	COSMIC	DKENGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95997	Securin	DEG_Kelch_Keap1_1	8:13	DKENGE	KEAP1	0.9951	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_Kelch_Keap1_1	588:593	DKENGE	KEAP1	0.9671	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_Kelch_Keap1_1	260:265	DKENGE	KEAP1	0.9527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons