DegronMD

Uniprot ID: Q9UGK3

Source protein: Signal-transducing adaptor protein 2

Source gene: STAP2

Class: DEG_APCC_KENBOX_2

Location: 260:264

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9715

ASA_SCORE: 88.94

COIL: 0.6638

CONS_SCORE: 0.5799

DSS_SCORE: 0.3243

HELIX: 0.2924

FCONS_SCORE: 1.1331

RIG_SCORE: 0.7268

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y256F	DO228349	MALY	ICGC	DKENG	DEG_APCC_KENBOX_2	0.6667
p.Y256F	SIDM00641	Burkitt's Lymphoma	GDSC	DKENG	DEG_APCC_KENBOX_2	0.6667
p.D260Y	SIDM01061	Oral Cavity Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	0.6214
p.D260N	TCGA-E9-A6HE	BRCA	TCGA	DKENG	DEG_APCC_KENBOX_2	0.5821
p.D260N	DO50048	BRCA	ICGC	DKENG	DEG_APCC_KENBOX_2	0.5821
p.Y250N	ACH-001735	Leukemia	CCLE	DKENG	DEG_APCC_KENBOX_2	0.5
p.V257M	SIDM01113	Other Sarcomas	GDSC	DKENG	DEG_APCC_KENBOX_2	0.25
p.K252N	TCGA-EE-A29G	SKCM	TCGA	DKENG	DEG_APCC_KENBOX_2	0.2222
p.K252N	DO47303	SKCM	ICGC	DKENG	DEG_APCC_KENBOX_2	0.2222
p.V269M	TCGA-D1-A103	UCEC	TCGA	DKENG	DEG_APCC_KENBOX_2	0.1944
p.V269M	DO42312	UCEC	ICGC	DKENG	DEG_APCC_KENBOX_2	0.1944
p.V269M	ACH-000999	Colon/Colorectal Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	0.1944
p.A270V	DO222973	BTCA	ICGC	DKENG	DEG_APCC_KENBOX_2	0.1667
p.P274A	SIDM00539	Esophageal Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	0.0556
p.P274A	ACH-001496	Esophageal Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55010	Eukaryotic translation initiation factor 5	DEG_APCC_KENBOX_2	167:171	DKENG	APC,CDC20,FZR1	0.6996	More...
Q6P1L5	Protein FAM117B	DEG_APCC_KENBOX_2	442:446	DKENG	APC,CDC20,FZR1	0.5729	More...
O95997	Securin	DEG_APCC_KENBOX_2	8:12	DKENG	APC,CDC20,FZR1	0.9977	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_APCC_KENBOX_2	260:264	DKENG	APC,CDC20,FZR1	0.9715	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_APCC_KENBOX_2	588:592	DKENG	APC,CDC20,FZR1	0.8823	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons