DegronMD

Uniprot ID: Q6P1L5

Source protein: Protein FAM117B

Source gene: FAM117B

Class: DEG_APCC_KENBOX_2

Location: 442:446

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5729

ASA_SCORE: 89.54

COIL: 0.8252

CONS_SCORE: 0.4529

DSS_SCORE: 0.6804

HELIX: 0.142

FCONS_SCORE: 0.7753

RIG_SCORE: 0.5974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D435Y	TCGA-BS-A0UV	UCEC	TCGA	DKENG	DEG_APCC_KENBOX_2	0.1389
p.Y454H	TCGA-FR-A8YC	SKCM	TCGA	DKENG	DEG_APCC_KENBOX_2	0.5556
p.P452L	TCGA-VQ-A8PP	STAD	TCGA	DKENG	DEG_APCC_KENBOX_2	0.1667
p.T456A	SIDM01045	Endometrial Carcinoma	GDSC	DKENG	DEG_APCC_KENBOX_2	0.5
p.T456A	ACH-000978	Endometrial/Uterine Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	0.5
p.T456A	EN	endometrium	COSMIC	DKENG	DEG_APCC_KENBOX_2	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95997	Securin	DEG_APCC_KENBOX_2	8:12	DKENG	APC,CDC20,FZR1	0.9977	More...
P55010	Eukaryotic translation initiation factor 5	DEG_APCC_KENBOX_2	167:171	DKENG	APC,CDC20,FZR1	0.6996	More...
Q6P1L5	Protein FAM117B	DEG_APCC_KENBOX_2	442:446	DKENG	APC,CDC20,FZR1	0.5729	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_APCC_KENBOX_2	588:592	DKENG	APC,CDC20,FZR1	0.8823	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_APCC_KENBOX_2	260:264	DKENG	APC,CDC20,FZR1	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons