DegronMD

Uniprot ID: O95997

Source protein: Securin

Source gene: PTTG1

Class: DEG_APCC_KENBOX_2

Location: 8:12

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9977

ASA_SCORE: 68.48

COIL: 0.6722

CONS_SCORE: 0.8314

DSS_SCORE: 0.4278

HELIX: 0.1004

FCONS_SCORE: 1.2684

RIG_SCORE: 0.7388

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I5S	SIDM01043	Other Sarcomas	GDSC	DKENG	DEG_APCC_KENBOX_2	0.6944
p.I5S	ACH-000913	Endometrial/Uterine Cancer	CCLE	DKENG	DEG_APCC_KENBOX_2	0.6944
p.I5S	ESS-1	endometrium	COSMIC	DKENG	DEG_APCC_KENBOX_2	0.6944
p.E10D	DO8264	COAD	ICGC	DKENG	DEG_APCC_KENBOX_2	0.6758
p.R17L	DO229031	LICA	ICGC	DKENG	DEG_APCC_KENBOX_2	0.1944
p.D22Y	DO228948	LICA	ICGC	DKENG	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55010	Eukaryotic translation initiation factor 5	DEG_APCC_KENBOX_2	167:171	DKENG	APC,CDC20,FZR1	0.6996	More...
Q6P1L5	Protein FAM117B	DEG_APCC_KENBOX_2	442:446	DKENG	APC,CDC20,FZR1	0.5729	More...
O95997	Securin	DEG_APCC_KENBOX_2	8:12	DKENG	APC,CDC20,FZR1	0.9977	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_APCC_KENBOX_2	260:264	DKENG	APC,CDC20,FZR1	0.9715	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_APCC_KENBOX_2	588:592	DKENG	APC,CDC20,FZR1	0.8823	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons