DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DKENG
Uniprot ID:
O95997
Source protein:
Securin
Source gene:
PTTG1
Class:
DEG_APCC_KENBOX_2
Location:
8:12
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9977
ASA_SCORE:
68.48
COIL:
0.6722
CONS_SCORE:
0.8314
DSS_SCORE:
0.4278
HELIX:
0.1004
FCONS_SCORE:
1.2684
RIG_SCORE:
0.7388
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E10D
DO8264
COAD
ICGC
DKENG
DEG_APCC_KENBOX_2
0.6758
p.D22Y
DO228948
LICA
ICGC
DKENG
DEG_APCC_KENBOX_2
0.0556
p.R17L
DO229031
LICA
ICGC
DKENG
DEG_APCC_KENBOX_2
0.1944
p.I5S
SIDM01043
Other Sarcomas
GDSC
DKENG
DEG_APCC_KENBOX_2
0.6944
p.I5S
ACH-000913
Endometrial/Uterine Cancer
CCLE
DKENG
DEG_APCC_KENBOX_2
0.6944
p.I5S
ESS-1
endometrium
COSMIC
DKENG
DEG_APCC_KENBOX_2
0.6944
Drug responses associated with PTTG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DKENG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95997
Securin
DEG_APCC_KENBOX_2
8:12
DKENG
APC,CDC20,FZR1
0.9977
More...
P55010
Eukaryotic translation initiation factor 5
DEG_APCC_KENBOX_2
167:171
DKENG
APC,CDC20,FZR1
0.6996
More...
Q6P1L5
Protein FAM117B
DEG_APCC_KENBOX_2
442:446
DKENG
APC,CDC20,FZR1
0.5729
More...
Q6UVJ0
Spindle assembly abnormal protein 6 homolog
DEG_APCC_KENBOX_2
588:592
DKENG
APC,CDC20,FZR1
0.8823
More...
Q9UGK3
Signal-transducing adaptor protein 2
DEG_APCC_KENBOX_2
260:264
DKENG
APC,CDC20,FZR1
0.9715
More...