DegronMD

Uniprot ID: Q96L93

Source protein: Kinesin-like protein KIF16B

Source gene: KIF16B

Class: DEG_SPOP_SBC_1

Location: 1096:1100

E3 ligase: SPOP

DEGRON score: 0.9957

ASA_SCORE: 81.5

COIL: 0.7924

CONS_SCORE: 0.2379

DSS_SCORE: 0.4807

HELIX: 0.0938

FCONS_SCORE: 0.9729

RIG_SCORE: 0.6847

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1099F	TCGA-W3-AA1V	SKCM	TCGA	VASSS	DEG_SPOP_SBC_1	0.9093
p.S1099F	DO51276	SKCM	ICGC	VASSS	DEG_SPOP_SBC_1	0.9093
p.S1100G	TCGA-E9-A1RF	BRCA	TCGA	VASSS	DEG_SPOP_SBC_1	0.8104
p.S1100G	DO2665	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	0.8104
p.S1099T	SIDM00656	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.7116
p.S1099T	ACH-000944	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	0.7116
p.S1099T	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.7116
p.A1097T	DO228414	MALY	ICGC	VASSS	DEG_SPOP_SBC_1	0.6028
p.S1108L	TCGA-EB-A5SG	SKCM	TCGA	VASSS	DEG_SPOP_SBC_1	0.5556
p.S1108L	DO48726	SKCM	ICGC	VASSS	DEG_SPOP_SBC_1	0.5556
p.L1101V	TCGA-AD-6548	COAD	TCGA	VASSS	DEG_SPOP_SBC_1	0.3056
p.L1101V	DO9586	COAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.3056
p.A1105G	TCGA-EE-A2GU	SKCM	TCGA	VASSS	DEG_SPOP_SBC_1	0.1944
p.A1105G	DO37639	SKCM	ICGC	VASSS	DEG_SPOP_SBC_1	0.1944
p.A1105D	DO229015	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	0.1944
p.E1106D	TCGA-AX-A0J0	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	0.1667
p.E1106D	DO41133	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	0.1667
p.G1090W	DO233694	GACA	ICGC	VASSS	DEG_SPOP_SBC_1	0.1667

Showing 1 to 18 of 18 entries

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Drug responses associated with KIF16B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VASSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	931:935	VASSS	SPOP	0.6437	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2071:2075	VASSS	SPOP	0.8357	More...
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_SPOP_SBC_1	247:251	VASSS	SPOP	0.9642	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2973:2977	VASSS	SPOP	0.9629	More...
Q9BWW9	Apolipoprotein L5	DEG_SPOP_SBC_1	140:144	VASSS	SPOP	0.5682	More...
Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14	DEG_SPOP_SBC_1	196:200	VASSS	SPOP	0.6707	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	888:892	VASSS	SPOP	0.8649	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1037:1041	VASSS	SPOP	0.5544	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1391:1395	VASSS	SPOP	0.9996	More...
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_SPOP_SBC_1	387:391	VASSS	SPOP	0.9672	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1040:1044	VASSS	SPOP	0.9979	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	570:574	VASSS	SPOP	0.9829	More...
P57058	Hormonally up-regulated neu tumor-associated kinase	DEG_SPOP_SBC_1	513:517	VASSS	SPOP	0.9759	More...
Q96L93	Kinesin-like protein KIF16B	DEG_SPOP_SBC_1	1096:1100	VASSS	SPOP	0.9957	More...
Q86Y91	Kinesin-like protein KIF18B	DEG_SPOP_SBC_1	787:791	VASSS	SPOP	0.9955	More...
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	63:67	VASSS	SPOP	0.9895	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	187:191	VASSS	SPOP	0.9697	More...
Q9NRR6	Phosphatidylinositol polyphosphate 5-phosphatase type IV	DEG_SPOP_SBC_1	164:168	VASSS	SPOP	0.9986	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1202:1206	VASSS	SPOP	0.9307	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1052:1056	VASSS	SPOP	0.9974	More...
Q8IYM0	Protein FAM186B	DEG_SPOP_SBC_1	859:863	VASSS	SPOP	0.9006	More...
Q5T0W9	Protein FAM83B	DEG_SPOP_SBC_1	425:429	VASSS	SPOP	0.9994	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	230:234	VASSS	SPOP	0.9994	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1700:1704	VASSS	SPOP	0.9907	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_SPOP_SBC_1	327:331	VASSS	SPOP	0.9253	More...

Showing 1 to 25 of 30 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASSS

Degron related mutations and impact score

Drug responses associated with KIF16B mutations

All proteins holding degron of VASSS