DegronMD - Q9NRR6(INPP5E)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P160L	TCGA-AX-A2HD	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2222
p.P160L	DO42608	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2222
p.V558I	TCGA-CM-5349	COAD	TCGA	DICPVSYSSCP	CBL_PTK	567:577	Mutation rewiring degron network	0.0833
p.V558I	DO8487	COAD	ICGC	DICPVSYSSCP	CBL_PTK	567:577	Mutation rewiring degron network	0.0833
p.V558I	DO42673	UCEC	ICGC	DICPVSYSSCP	CBL_PTK	567:577	Mutation rewiring degron network	0.0833
p.V558I	ACH-000989	Colon/Colorectal Cancer	CCLE	DICPVSYSSCP	CBL_PTK	567:577	Mutation rewiring degron network	0.0833
p.D583N	DO229489	LAML	ICGC	DICPVSYSSCP	CBL_PTK	567:577	Mutation rewiring degron network	0.1667
p.D567E	DO228978	LICA	ICGC	DICPVSYSSCP	CBL_PTK	567:577	Mutation altering degron motif	0.6758
p.T581K	DO228971	LICA	ICGC	DICPVSYSSCP	CBL_PTK	567:577	Mutation rewiring degron network	0.2222
p.D175E	DO229031	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.I70F	DO27817	MALY	ICGC	PATPSGE	DEG_SCF_FBW7_2	55:61	Mutation rewiring degron network	0.0833
p.P570H	DO232224	PBCA	ICGC	DICPVSYSSCP	CBL_PTK	567:577	Mutation altering degron motif	0.6583
p.P154S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.P154S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.P154S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.S156L	SIDM00080	Melanoma	GDSC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation blocking phosphorylation signal	0.5556
p.S156L	ACH-000730	Skin Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	164:168	Mutation blocking phosphorylation signal	0.5556
p.S156L	SK-MEL-5	skin	COSMIC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation blocking phosphorylation signal	0.5556
p.G157W	SIDM01184	Bladder Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.G157W	SIDM00006	Other Solid Cancers	GDSC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.G157W	MCC26	skin	COSMIC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.V178M	SIDM01113	Other Sarcomas	GDSC	VASSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.R585H	ACH-000999	Colon/Colorectal Cancer	CCLE	DICPVSYSSCP	CBL_PTK	567:577	Mutation rewiring degron network	0.1111

Kaplan plot for INPP5E in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INPP5E

UniProt ID: Q9NRR6

Entrez ID: 56623

Protein name: Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INPP5E in