DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DICPVSYSSCP
Uniprot ID:
Q9NRR6
Source protein:
Phosphatidylinositol polyphosphate 5-phosphatase type IV
Source gene:
INPP5E
Class:
CBL_PTK
Location:
567:577
E3 ligase:
CBL
DEGRON score:
0.8793
ASA_SCORE:
48.6455
COIL:
0.4789
CONS_SCORE:
0.4604
DSS_SCORE:
0.3318
HELIX:
0.0252
FCONS_SCORE:
0.7179
RIG_SCORE:
0.7394
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V558I
TCGA-CM-5349
COAD
TCGA
DICPVSYSSCP
CBL_PTK
0.0833
p.V558I
DO8487
COAD
ICGC
DICPVSYSSCP
CBL_PTK
0.0833
p.V558I
DO42673
UCEC
ICGC
DICPVSYSSCP
CBL_PTK
0.0833
p.V558I
ACH-000989
Colon/Colorectal Cancer
CCLE
DICPVSYSSCP
CBL_PTK
0.0833
p.D583N
DO229489
LAML
ICGC
DICPVSYSSCP
CBL_PTK
0.1667
p.D567E
DO228978
LICA
ICGC
DICPVSYSSCP
CBL_PTK
0.6758
p.T581K
DO228971
LICA
ICGC
DICPVSYSSCP
CBL_PTK
0.2222
p.P570H
DO232224
PBCA
ICGC
DICPVSYSSCP
CBL_PTK
0.6583
p.R585H
ACH-000999
Colon/Colorectal Cancer
CCLE
DICPVSYSSCP
CBL_PTK
0.1111
Drug responses associated with INPP5E mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DICPVSYSSCP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NRR6
Phosphatidylinositol polyphosphate 5-phosphatase type IV
CBL_PTK
567:577
DICPVSYSSCP
CBL
0.8793
More...
