DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SPOP_SBC_1

Location: 351:355

E3 ligase: SPOP

DEGRON score: 0.9052

ASA_SCORE: 55.92

COIL: 0.4634

CONS_SCORE: 0.4445

DSS_SCORE: 0.5676

HELIX: 0.0732

FCONS_SCORE: 0.8793

RIG_SCORE: 0.6939

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S355Y	TCGA-13-0757	OV	TCGA	VASSS	DEG_SPOP_SBC_1	0.712
p.S355Y	DO32576	OV	ICGC	VASSS	DEG_SPOP_SBC_1	0.712
p.P343L	TCGA-56-8082	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	0.1111
p.P343L	DO223722	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	0.1111
p.E348G	TCGA-85-8580	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	0.25
p.E348G	DO45549	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	0.25
p.Q347R	TCGA-85-8580	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	0.2222
p.Q347R	DO45549	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	0.2222
p.A352T	TCGA-AX-A06F	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	0.6028
p.A352T	DO41752	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	0.6028
p.P343T	TCGA-CR-7398	HNSC	TCGA	VASSS	DEG_SPOP_SBC_1	0.1111
p.P343T	DO14782	HNSC	ICGC	VASSS	DEG_SPOP_SBC_1	0.1111
p.V351M	TCGA-VQ-A8P2	STAD	TCGA	VASSS	DEG_SPOP_SBC_1	0.7208
p.V351M	DO51761	STAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.7208
p.K346M	DO234235	ESAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.3056
p.T365K	DO229038	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	0.0556
p.A352D	DO229045	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	0.6682
p.R360T	SIDM00933	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R360T	SIDM00967	Ovarian Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R360T	SIDM01055	Glioblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R360T	SIDM00094	Kidney Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R360T	SIDM00136	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R360T	SIDM00875	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R360T	SIDM00954	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R360T	SIDM00224	Mesothelioma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.G349D	SIDM00878	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.2778
p.G349D	ACH-000930	Breast Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.2778
p.G349D	HCC1569	breast	COSMIC	VASSS	DEG_SPOP_SBC_1	0.2778
p.T363M	SIDM01608	Endometrial Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1111
p.T363M	ACH-000990	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.1111
p.K346R	ACH-001786	Colon/Colorectal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.3056
p.S354A	ACH-002446	Gastric Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	63:67	VASSS	SPOP	0.9895	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2071:2075	VASSS	SPOP	0.8357	More...
P57058	Hormonally up-regulated neu tumor-associated kinase	DEG_SPOP_SBC_1	513:517	VASSS	SPOP	0.9759	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2973:2977	VASSS	SPOP	0.9629	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	290:294	VASSS	SPOP	0.9979	More...
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_SPOP_SBC_1	387:391	VASSS	SPOP	0.9672	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	187:191	VASSS	SPOP	0.9697	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1052:1056	VASSS	SPOP	0.9974	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1202:1206	VASSS	SPOP	0.9307	More...
Q5SNT2	Transmembrane protein 201	DEG_SPOP_SBC_1	514:518	VASSS	SPOP	0.9614	More...
Q5T0W9	Protein FAM83B	DEG_SPOP_SBC_1	425:429	VASSS	SPOP	0.9994	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1700:1704	VASSS	SPOP	0.9907	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	931:935	VASSS	SPOP	0.6437	More...
Q86Y91	Kinesin-like protein KIF18B	DEG_SPOP_SBC_1	787:791	VASSS	SPOP	0.9955	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	351:355	VASSS	SPOP	0.9052	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	445:449	VASSS	SPOP	0.6862	More...
Q96L93	Kinesin-like protein KIF16B	DEG_SPOP_SBC_1	1096:1100	VASSS	SPOP	0.9957	More...
Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14	DEG_SPOP_SBC_1	196:200	VASSS	SPOP	0.6707	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1040:1044	VASSS	SPOP	0.9979	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	570:574	VASSS	SPOP	0.9829	More...
Q9NRR6	Phosphatidylinositol polyphosphate 5-phosphatase type IV	DEG_SPOP_SBC_1	164:168	VASSS	SPOP	0.9986	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	888:892	VASSS	SPOP	0.8649	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_SPOP_SBC_1	327:331	VASSS	SPOP	0.9253	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1391:1395	VASSS	SPOP	0.9996	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1037:1041	VASSS	SPOP	0.5544	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	230:234	VASSS	SPOP	0.9994	More...
Q8IYM0	Protein FAM186B	DEG_SPOP_SBC_1	859:863	VASSS	SPOP	0.9006	More...
Q9BWW9	Apolipoprotein L5	DEG_SPOP_SBC_1	140:144	VASSS	SPOP	0.5682	More...
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_SPOP_SBC_1	247:251	VASSS	SPOP	0.9642	More...
Q5SVZ6	Zinc finger MYM-type protein 1	DEG_SPOP_SBC_1	395:399	VASSS	SPOP	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASSS

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of VASSS