DegronMD - Q5T0W9(FAM83B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V425L	TCGA-21-5787	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.6765
p.V425L	DO26605	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.6765
p.L789I	TCGA-AN-A046	BRCA	TCGA	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation altering degron motif	0.6063
p.L789I	DO1285	BRCA	ICGC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation altering degron motif	0.6063
p.K418N	TCGA-B5-A3FC	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	425:429	Mutation substituting flanking lysine	0.25
p.K418N	DO41871	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation substituting flanking lysine	0.25
p.A426V	TCGA-BR-8059	STAD	TCGA	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.5825
p.A426V	DO38443	STAD	ICGC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.5825
p.S429P	TCGA-D8-A1XQ	BRCA	TCGA	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.7863
p.S429P	DO3095	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.7863
p.S424R	TCGA-EO-A22X	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.75
p.S424R	DO43907	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.75
p.A796V	DO231906	LINC	ICGC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.1389
p.A426S	DO23344	LINC	ICGC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.6477
p.S429L	DO220886	MELA	ICGC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.8778
p.S435R	SIDM00672	Hepatocellular Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01265	Plasma Cell Myeloma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01090	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01117	Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00654	Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00690	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01112	Osteosarcoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01099	Neuroblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00529	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00650	Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00878	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01247	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00793	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01133	Other Solid Cancers	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01681	Non-Cancerous	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00257	Neuroblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM00720	Mesothelioma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01409	Bladder Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S435R	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation blocking phosphorylation signal	0.6111
p.S427Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.8231
p.S427Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.8231
p.S427Y	ACH-000995	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.8231
p.S427Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation altering degron motif	0.8231
p.S790F	SIDM00545	Melanoma	GDSC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.3056
p.S790F	SIDM00527	Colorectal Carcinoma	GDSC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.3056
p.S790F	ACH-000935	Colon/Colorectal Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.3056
p.S790F	ACH-000987	Skin Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.3056
p.S790F	Mewo	skin	COSMIC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.3056
p.S790F	MDST8	large intestine	COSMIC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.3056
p.A794S	SIDM00198	Ewing's Sarcoma	GDSC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.1944
p.A794S	ACH-002114	Bone Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.1944
p.A794S	EW-16	bone	COSMIC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.1944
p.P783S	SIDM01133	Other Solid Cancers	GDSC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.2778
p.P783S	ACH-002177	Lung Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.2778
p.P783S	NCI-H835	lung	COSMIC	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.2778
p.R430W	SIDM01619	Endometrial Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	425:429	Mutation rewiring degron network	0.3056
p.R430W	ACH-000984	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	425:429	Mutation rewiring degron network	0.3056
p.S790P	ACH-001607	Gallbladder Cancer	CCLE	KKENL	DEG_APCC_KENBOX_2	785:789	Mutation rewiring degron network	0.3056
p.K418R	ACH-001786	Colon/Colorectal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	425:429	Mutation substituting flanking lysine	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM83B

UniProt ID: Q5T0W9

Entrez ID: 222584

Protein name: Protein FAM83B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM83B in