DegronMD

Uniprot ID: Q5T0W9

Source protein: Protein FAM83B

Source gene: FAM83B

Class: DEG_SPOP_SBC_1

Location: 425:429

E3 ligase: SPOP

DEGRON score: 0.9994

ASA_SCORE: 72.12

COIL: 0.878

CONS_SCORE: 0.6542

DSS_SCORE: 0.5216

HELIX: 0.097

FCONS_SCORE: 1.0645

RIG_SCORE: 0.5968

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V425L	TCGA-21-5787	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	0.6765
p.V425L	DO26605	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	0.6765
p.K418N	TCGA-B5-A3FC	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	0.25
p.K418N	DO41871	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	0.25
p.A426V	TCGA-BR-8059	STAD	TCGA	VASSS	DEG_SPOP_SBC_1	0.5825
p.A426V	DO38443	STAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.5825
p.S429P	TCGA-D8-A1XQ	BRCA	TCGA	VASSS	DEG_SPOP_SBC_1	0.7863
p.S429P	DO3095	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	0.7863
p.S424R	TCGA-EO-A22X	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	0.75
p.S424R	DO43907	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	0.75
p.A426S	DO23344	LINC	ICGC	VASSS	DEG_SPOP_SBC_1	0.6477
p.S429L	DO220886	MELA	ICGC	VASSS	DEG_SPOP_SBC_1	0.8778
p.S435R	SIDM00672	Hepatocellular Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01265	Plasma Cell Myeloma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01090	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01117	Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00654	Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00690	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01112	Osteosarcoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01099	Neuroblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00529	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00650	Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00878	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01247	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00793	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01133	Other Solid Cancers	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01681	Non-Cancerous	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00257	Neuroblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM00720	Mesothelioma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01409	Bladder Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S435R	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.6111
p.S427Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	0.8231
p.S427Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	0.8231
p.S427Y	ACH-000995	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	0.8231
p.S427Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.8231
p.R430W	SIDM01619	Endometrial Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.3056
p.R430W	ACH-000984	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.3056
p.K418R	ACH-001786	Colon/Colorectal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	63:67	VASSS	SPOP	0.9895	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2071:2075	VASSS	SPOP	0.8357	More...
P57058	Hormonally up-regulated neu tumor-associated kinase	DEG_SPOP_SBC_1	513:517	VASSS	SPOP	0.9759	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2973:2977	VASSS	SPOP	0.9629	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	290:294	VASSS	SPOP	0.9979	More...
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_SPOP_SBC_1	387:391	VASSS	SPOP	0.9672	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	187:191	VASSS	SPOP	0.9697	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1052:1056	VASSS	SPOP	0.9974	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1202:1206	VASSS	SPOP	0.9307	More...
Q5SNT2	Transmembrane protein 201	DEG_SPOP_SBC_1	514:518	VASSS	SPOP	0.9614	More...
Q5T0W9	Protein FAM83B	DEG_SPOP_SBC_1	425:429	VASSS	SPOP	0.9994	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1700:1704	VASSS	SPOP	0.9907	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	931:935	VASSS	SPOP	0.6437	More...
Q86Y91	Kinesin-like protein KIF18B	DEG_SPOP_SBC_1	787:791	VASSS	SPOP	0.9955	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	351:355	VASSS	SPOP	0.9052	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	445:449	VASSS	SPOP	0.6862	More...
Q96L93	Kinesin-like protein KIF16B	DEG_SPOP_SBC_1	1096:1100	VASSS	SPOP	0.9957	More...
Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14	DEG_SPOP_SBC_1	196:200	VASSS	SPOP	0.6707	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1040:1044	VASSS	SPOP	0.9979	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	570:574	VASSS	SPOP	0.9829	More...
Q9NRR6	Phosphatidylinositol polyphosphate 5-phosphatase type IV	DEG_SPOP_SBC_1	164:168	VASSS	SPOP	0.9986	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	888:892	VASSS	SPOP	0.8649	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_SPOP_SBC_1	327:331	VASSS	SPOP	0.9253	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1391:1395	VASSS	SPOP	0.9996	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1037:1041	VASSS	SPOP	0.5544	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	230:234	VASSS	SPOP	0.9994	More...
Q8IYM0	Protein FAM186B	DEG_SPOP_SBC_1	859:863	VASSS	SPOP	0.9006	More...
Q9BWW9	Apolipoprotein L5	DEG_SPOP_SBC_1	140:144	VASSS	SPOP	0.5682	More...
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_SPOP_SBC_1	247:251	VASSS	SPOP	0.9642	More...
Q5SVZ6	Zinc finger MYM-type protein 1	DEG_SPOP_SBC_1	395:399	VASSS	SPOP	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASSS

Degron related mutations and impact score

Drug responses associated with FAM83B mutations

All proteins holding degron of VASSS