DegronMD

Uniprot ID: Q86Y91

Source protein: Kinesin-like protein KIF18B

Source gene: KIF18B

Class: DEG_SPOP_SBC_1

Location: 787:791

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 84.78

COIL: 0.925

CONS_SCORE: 0.2343

DSS_SCORE: 0.5835

HELIX: 0.0386

FCONS_SCORE: 0.8149

RIG_SCORE: 0.6549

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S789I	TCGA-13-1500	OV	TCGA	VASSS	DEG_SPOP_SBC_1	0.8453
p.S789I	DO29698	OV	ICGC	VASSS	DEG_SPOP_SBC_1	0.8453
p.V787I	TCGA-14-0740	GBM	TCGA	VASSS	DEG_SPOP_SBC_1	0.7076
p.V787I	TCGA-AA-3845	COAD	TCGA	VASSS	DEG_SPOP_SBC_1	0.7076
p.V787I	TCGA-KN-8428	KICH	TCGA	VASSS	DEG_SPOP_SBC_1	0.7076
p.V787I	DO10020	COAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.7076
p.V787I	DO12058	GBM	ICGC	VASSS	DEG_SPOP_SBC_1	0.7076
p.V787I	DO220484	KICH	ICGC	VASSS	DEG_SPOP_SBC_1	0.7076
p.V787I	ACH-001610	Brain Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.7076
p.S791A	TCGA-CK-5916	COAD	TCGA	VASSS	DEG_SPOP_SBC_1	0.87
p.R796C	TCGA-FP-A4BE	STAD	TCGA	VASSS	DEG_SPOP_SBC_1	0.1944
p.R796C	DO48016	STAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R796H	TCGA-GL-A9DE	KIRP	TCGA	VASSS	DEG_SPOP_SBC_1	0.1944
p.R796H	DO51560	KIRP	ICGC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R796H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R796H	SIDM01451	Pancreatic Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R796H	ACH-000918	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	0.1944
p.R796H	ACH-000933	Pancreatic Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.1944
p.R796H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1944
p.R786H	DO225350	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	0.3056
p.P777H	DO6742	CLLE	ICGC	VASSS	DEG_SPOP_SBC_1	0.0556
p.S794A	DO8786	COAD	ICGC	VASSS	DEG_SPOP_SBC_1	0.25
p.R798H	DO228338	MALY	ICGC	VASSS	DEG_SPOP_SBC_1	0.1389
p.S790F	DO220861	MELA	ICGC	VASSS	DEG_SPOP_SBC_1	0.7982
p.R801H	DO220886	MELA	ICGC	VASSS	DEG_SPOP_SBC_1	0.0556
p.S787F	DO222753	MELA	ICGC	VASSS	DEG_SPOP_SBC_1	0.7982
p.P784S	DO37419	SKCM	ICGC	VASSS	DEG_SPOP_SBC_1	0.6944
p.A784S	DO229242	THCA	ICGC	VASSS	DEG_SPOP_SBC_1	0.6944
p.C782Y	SIDM01261	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.1944
p.C782Y	ACH-000097	Breast Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.1944
p.C782Y	ACH-002208	Breast Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.1944
p.C782Y	YMB-1-E	breast	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1944
p.A800T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	0.0833
p.A800T	ACH-001669	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	0.0833
p.A800T	ACH-002238	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	0.0833
p.A800T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.0833
p.R786L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	0.3056
p.R786L	H513	pleura	COSMIC	VASSS	DEG_SPOP_SBC_1	0.3056
p.R786C	ACH-000964	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	0.3056
p.S791L	ACH-001698	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	0.8778
p.G790D	NCI-H1155	lung	COSMIC	VASSS	DEG_SPOP_SBC_1	0.7198
p.C794Y	YMB-1-E	breast	COSMIC	VASSS	DEG_SPOP_SBC_1	0.25
p.G781V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1667
p.G781D	NCI-H1155	lung	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1667
p.R798L	H513	pleura	COSMIC	VASSS	DEG_SPOP_SBC_1	0.1389
p.G790V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	63:67	VASSS	SPOP	0.9895	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2071:2075	VASSS	SPOP	0.8357	More...
P57058	Hormonally up-regulated neu tumor-associated kinase	DEG_SPOP_SBC_1	513:517	VASSS	SPOP	0.9759	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	2973:2977	VASSS	SPOP	0.9629	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	290:294	VASSS	SPOP	0.9979	More...
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_SPOP_SBC_1	387:391	VASSS	SPOP	0.9672	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	187:191	VASSS	SPOP	0.9697	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1052:1056	VASSS	SPOP	0.9974	More...
Q5JUK3	Potassium channel subfamily T member 1	DEG_SPOP_SBC_1	1202:1206	VASSS	SPOP	0.9307	More...
Q5SNT2	Transmembrane protein 201	DEG_SPOP_SBC_1	514:518	VASSS	SPOP	0.9614	More...
Q5T0W9	Protein FAM83B	DEG_SPOP_SBC_1	425:429	VASSS	SPOP	0.9994	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1700:1704	VASSS	SPOP	0.9907	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	931:935	VASSS	SPOP	0.6437	More...
Q86Y91	Kinesin-like protein KIF18B	DEG_SPOP_SBC_1	787:791	VASSS	SPOP	0.9955	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	351:355	VASSS	SPOP	0.9052	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	445:449	VASSS	SPOP	0.6862	More...
Q96L93	Kinesin-like protein KIF16B	DEG_SPOP_SBC_1	1096:1100	VASSS	SPOP	0.9957	More...
Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14	DEG_SPOP_SBC_1	196:200	VASSS	SPOP	0.6707	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	1040:1044	VASSS	SPOP	0.9979	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	570:574	VASSS	SPOP	0.9829	More...
Q9NRR6	Phosphatidylinositol polyphosphate 5-phosphatase type IV	DEG_SPOP_SBC_1	164:168	VASSS	SPOP	0.9986	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	888:892	VASSS	SPOP	0.8649	More...
Q9UGK3	Signal-transducing adaptor protein 2	DEG_SPOP_SBC_1	327:331	VASSS	SPOP	0.9253	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1391:1395	VASSS	SPOP	0.9996	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1037:1041	VASSS	SPOP	0.5544	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	230:234	VASSS	SPOP	0.9994	More...
Q8IYM0	Protein FAM186B	DEG_SPOP_SBC_1	859:863	VASSS	SPOP	0.9006	More...
Q9BWW9	Apolipoprotein L5	DEG_SPOP_SBC_1	140:144	VASSS	SPOP	0.5682	More...
Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	DEG_SPOP_SBC_1	247:251	VASSS	SPOP	0.9642	More...
Q5SVZ6	Zinc finger MYM-type protein 1	DEG_SPOP_SBC_1	395:399	VASSS	SPOP	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASSS

Degron related mutations and impact score

Drug responses associated with KIF18B mutations

All proteins holding degron of VASSS