DegronMD - Q9BWW9(APOL5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q389H	TCGA-AP-A059	UCEC	TCGA	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation rewiring degron network	0.0833
p.Q389H	DO41361	UCEC	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation rewiring degron network	0.0833
p.V405I	TCGA-AX-A2HD	UCEC	TCGA	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation rewiring degron network	0.3056
p.V405I	DO42608	UCEC	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation rewiring degron network	0.3056
p.L134F	TCGA-BB-8596	HNSC	TCGA	VASSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1667
p.L134F	DO15599	HNSC	ICGC	VASSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1667
p.M151I	TCGA-BK-A6W3	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1389
p.M151I	DO50076	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1389
p.S406C	DO229010	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation blocking phosphorylation signal	0.7222
p.S406C	DO229013	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation blocking phosphorylation signal	0.7222
p.S406C	DO229016	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation blocking phosphorylation signal	0.7222
p.S406C	DO229003	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation blocking phosphorylation signal	0.7222
p.S406C	DO229005	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation blocking phosphorylation signal	0.7222
p.S406C	DO234285	ESAD	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation blocking phosphorylation signal	0.7222
p.G393R	DO220849	MELA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation rewiring degron network	0.1944
p.G393D	DO229250	THCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	398:404	Mutation rewiring degron network	0.1944
p.L133M	SIDM00928	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1389
p.L133M	CAL-85-1	breast	COSMIC	VASSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1389

Kaplan plot for APOL5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APOL5

UniProt ID: Q9BWW9

Entrez ID: 80831

Protein name: Apolipoprotein L5 (Apolipoprotein L-V) (ApoL-V)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for APOL5 in