DegronMD

Uniprot ID: Q9BWW9

Source protein: Apolipoprotein L5

Source gene: APOL5

Class: DEG_SCF_FBW7_1

Location: 398:404

E3 ligase: FBXW7

DEGRON score: 0.7471

ASA_SCORE: 97.7571

COIL: 0.7627

CONS_SCORE: 0.0139

DSS_SCORE: 0.6756

HELIX: 0.0366

FCONS_SCORE: 1

RIG_SCORE: 0.6912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q389H	TCGA-AP-A059	UCEC	TCGA	LRTPKRT	DEG_SCF_FBW7_1	0.0833
p.Q389H	DO41361	UCEC	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.0833
p.V405I	TCGA-AX-A2HD	UCEC	TCGA	LRTPKRT	DEG_SCF_FBW7_1	0.3056
p.V405I	DO42608	UCEC	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.3056
p.S406C	DO229010	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.7222
p.S406C	DO229013	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.7222
p.S406C	DO229016	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.7222
p.S406C	DO229003	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.7222
p.S406C	DO229005	COCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.7222
p.S406C	DO234285	ESAD	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.7222
p.G393R	DO220849	MELA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.1944
p.G393D	DO229250	THCA	ICGC	LRTPKRT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWW9	Apolipoprotein L5	DEG_SCF_FBW7_1	398:404	LRTPKRT	FBXW7	0.7471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons