DegronMD - Q8IYM0(FAM186B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S863G	TCGA-D1-A1NZ	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	859:863	Mutation altering degron motif	0.6993
p.S863G	DO41536	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation altering degron motif	0.6993
p.M851T	SIDM00321	Ovarian Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1111
p.M851T	SIDM00351	Oral Cavity Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1111
p.M851T	ACH-000430	Ovarian Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1111
p.M851T	ACH-002029	Head and Neck Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1111
p.M851T	SAS	upper aerodigestive tract	COSMIC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1111
p.M851T	TYK-nu	ovary	COSMIC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1111
p.E852D	SIDM00789	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1389
p.E852D	SIDM00794	Other Solid Cancers	GDSC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1389
p.E852D	SIDM00179	Melanoma	GDSC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1389
p.E852D	SIDM00044	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1389
p.A865T	SIDM00832	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2778
p.A865T	ACH-000680	Colon/Colorectal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2778
p.A865T	SW948	large intestine	COSMIC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2778
p.I866K	SIDM01619	Endometrial Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.25
p.I866K	ACH-000984	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.25

Kaplan plot for FAM186B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM186B

UniProt ID: Q8IYM0

Entrez ID: 84070

Protein name: Protein FAM186B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM186B in